Cardiovascular diseases (CVD), including heart and pathological circulatory conditions, are
the world's leading cause of mortality and morbidity. Endothelial dysfunction involved in …

The burden of heart failure (HF) in terms of health care expenditures, hospitalizations, and
mortality is substantial and growing. The failing heart has been described as “energy …

Healthy aging is the art of balancing a delicate scale. On one side of the scale, there are the
factors that make life difficult with aging, and on the other side are the products of human …

Negative alterations of mitochondria are known to occur in heart failure (HF). This study
investigated the novel mitochondrial-targeted therapeutic agent elamipretide on …

Mitochondria and peroxisomes are small ubiquitous organelles. They both play major roles
in cell metabolism, especially in terms of fatty acid metabolism, reactive oxygen species …

Mutations in the gene encoding the enzyme tafazzin, TAZ, cause Barth syndrome (BTHS).
Individuals with this X-linked multisystem disorder present cardiomyopathy (CM)(often …

Cardiac mitochondrial metabolism provides 90% of the ATP necessary for the contractile
exertion of the heart muscle. Mitochondria are therefore assumed to play a pivotal role in …

Mitochondrial oxidative damage and dysfunction contribute to a wide range of human
diseases. Considering the limitation of conventional antioxidants and that mitochondria are …

Cardiolipin (CL), the signature phospholipid of mitochondrial membranes, is crucial for both
mitochondrial function and cellular processes outside of the mitochondria. The importance of …

Oxidative stress is considered to be the primary cause of many cardiovascular diseases,
including endothelial dysfunction in atherosclerosis and ischemic heart disease …