[HTML][HTML] Glucagon-like peptide 1 (GLP-1)

TD Müller, B Finan, SR Bloom, D D'Alessio… - Molecular …, 2019 - Elsevier
Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …

Complex regulatory effects of gut microbial short-chain fatty acids on immune tolerance and autoimmunity

CH Kim - Cellular & molecular immunology, 2023 - nature.com
Immune tolerance deletes or suppresses autoreactive lymphocytes and is established at
multiple levels during the development, activation and effector phases of T and B cells …

Pharmacotherapy of obesity: available medications and drugs under investigation

E Pilitsi, OM Farr, SA Polyzos, N Perakakis… - Metabolism, 2019 - Elsevier
Obesity is a chronic disease with a continuously rising prevalence that currently affects more
than half a billion people worldwide. Energy balance and appetite are highly regulated via …

Brain GLP‐1 and the regulation of food intake: GLP‐1 action in the brain and its implications for GLP‐1 receptor agonists in obesity treatment

S Trapp, DI Brierley - British Journal of Pharmacology, 2022 - Wiley Online Library
This review considers the similarities and differences between the physiological systems
regulated by gut‐derived and neuronally produced glucagon‐like peptide 1 (GLP‐1). It …

Milestones in the journey towards addressing obesity; Past trials and triumphs, recent breakthroughs, and an exciting future in the era of emerging effective medical …

M Kokkorakis, A Katsarou, N Katsiki, CS Mantzoros - Metabolism, 2023 - Elsevier
The 21st century is characterized by an increasing incidence and prevalence of obesity and
the burden of its associated comorbidities, especially cardiometabolic diseases, which are …

The incretin/glucagon system as a target for pharmacotherapy of obesity

S Del Prato, B Gallwitz, JJ Holst, JJ Meier - Obesity Reviews, 2022 - Wiley Online Library
Obesity is a chronic, multifactorial, relapsing disease. Despite multicomponent lifestyle
interventions, including pharmacotherapy, maintaining bodyweight loss is challenging for …

Advances in obesity pharmacotherapy; learning from metabolic surgery and beyond

D Tsilingiris, A Kokkinos - Metabolism, 2024 - Elsevier
Currently, metabolic surgery (MS) constitutes the most effective means for durable weight
loss of clinically meaningful magnitude, type 2 diabetes remission and resolution of non …

Do gut hormones contribute to weight loss and glycaemic outcomes after bariatric surgery?

D Papamargaritis, CW le Roux - Nutrients, 2021 - mdpi.com
Bariatric surgery is an effective intervention for management of obesity through treating
dysregulated appetite and achieving long-term weight loss maintenance. Moreover …

Effect of sleeve gastrectomy on ghrelin, GLP-1, PYY, and GIP gut hormones: a systematic review and meta-analysis

TR McCarty, P Jirapinyo, CC Thompson - Annals of surgery, 2020 - journals.lww.com
Objective: To perform a structured systematic review and meta-analysis to evaluate changes
in ghrelin, glucagon-like peptide-1 (GLP-1), peptide YY (PYY), and gastric inhibitory peptide …

[HTML][HTML] Obesity and reproduction: a committee opinion

A Penzias, R Azziz, K Bendikson, T Falcone… - Fertility and sterility, 2021 - Elsevier
The purpose of this American Society for Reproductive Medicine Practice Committee report
is to provide clinicians with principles and strategies for the evaluation and treatment of …