Monoclonal antibodies (mAbs) have become one of the most important classes of
biopharmaceutical products, and they continue to dominate the universe of …

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome describing patients with severe
systemic hyperinflammation. Characteristic features include unremitting fever, cytopenias …

Background T cell mediated hyperinflammatory responses such as cytokine release
syndrome (CRS) and immune effector cell associated neurotoxicity syndrome (ICANS) are …

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathologic immune activation,
often associated with genetic defects of lymphocyte cytotoxicity. Though a distinctive …

The term cytokine storm syndromes describes conditions characterised by a life-threatening,
fulminant hypercytokinaemia with high mortality. Cytokine storm syndromes can be genetic …

The historic term 'histiocytosis' meaning 'tissue cell'is used as a unifying concept for
diseases characterized by pathogenic myeloid cells that share histological features with …

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory
syndrome comprising familial/genetic HLH (FHL) and secondary HLH. In the HLH-94 study …

Background Hemophagocytic lymphohistiocytosis is a cytokine-driven inflammatory
syndrome that is associated with substantial morbidity and mortality. Overall survival in adult …

Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening state of immune
hyperactivation that arises in the setting of genetic mutations and infectious, inflammatory, or …

Hemophagocytic lymphohistiocytosis is a life-threatening disorder characterized by
unbridled activation of cytotoxic T lymphocytes, natural killer (NK) cells, and macrophages …