The twenty-first century has witnessed major developments in the field of extracellular
vesicle (EV) research, including significant steps towards defining standard criteria for the …

With the increase of population aging, the number of Alzheimer's disease (AD) patients is
also increasing. According to current estimates, approximately 11% of people over 65 suffer …

Modern drug discovery methods led to evolving new agents with significant therapeutic
potential. However, their properties, such as solubility and administration-related …

Diseases of the central nervous system (CNS) are challenging to treat, mainly due to the
blood-brain barrier (BBB), which restricts drugs in circulation from entering target regions in …

Crosstalk mechanisms between pericytes, endothelial cells, and astrocytes preserve
integrity and function of the blood-brain-barrier (BBB) under physiological conditions. Long …

Tissue-specific uptake and sufficient biodistribution are central goals in drug development.
Crossing the blood–brain barrier (BBB) represents a major challenge in delivering …

Neurodegenerative disorders are one of the most common causes of disability and
represent 6.3% of the global burden of disease. Among them, Alzheimer's, Parkinson's, and …

(1) Background: Huntington's disease (HD) is rare incurable hereditary neurodegenerative
disorder caused by CAG repeat expansion in the gene coding for the protein huntingtin …

Small extracellular vesicles (sEVs) have∼ 30–200 nm diameter size and may act as carriers
of different cargoes, depending on the cell of origin or on the physiological/pathological …

Inflammatory diseases are common pathological processes caused by various acute and
chronic factors, and some of them are autoimmune diseases. Exosomes are fundamental …