HT plays a crucial role in the progress and adjustment of pain both centrally and
peripherally. The therapeutic action of the 5-HT receptorsagonist and antagonist in …

Developmental and epileptic encephalopathies (DEEs) are complex conditions
characterized primarily by seizures associated with neurodevelopmental and motor deficits …

Curcumin, a phenolic compound present in Curcuma longa, has been reported to exert
antinociceptive effects in some animal models, but the mechanisms remain to be elucidated …

Activation of N-methyl-d-aspartate (NMDA) receptors in the spinal dorsal horn has been
shown to be essential for the initiation of central sensitization and the hyperexcitability of …

Abstract The Prader–Willi syndrome (PWS) genetic interval contains several brain-
expressed small nucleolar (sno) RNA species that are subject to genomic imprinting. In vitro …

Chronic neuropathic pain is a debilitating ordeal for patients worldwide and
pharmacological treatment efficacy is still limited. As many pharmacological interventions for …

Chronic primary pain (CPP) is a group of diseases with long‐term pain and functional
disorders but without structural or specific tissue pathologies. CPP is becoming a serious …

Monoamines are involved in regulating the endogenous pain system and indeed, peripheral
and central monoaminergic dysfunction has been demonstrated in certain types of pain …

Our previous study has reported that electroacupuncture (EA) at low frequency of 2 Hz had
greater and more prolonged analgesic effects on mechanical allodynia and thermal …

Antidepressants are often used for the treatment of neuropathic pain. Clinical studies
suggest that the efficacy of serotonin (5-HT) and noradrenaline (NA) reuptake inhibitors …