Humans, like all mammals, partition their daily behaviour into activity (wakefulness) and rest
(sleep) phases that differ largely in their metabolic requirements. The circadian clock …

Circadian rhythms are a ubiquitous feature of virtually all living organisms, regulating a wide
diversity of physiological systems. It has long been established that the circadian clockwork …

The accurate definition and staging of chronic kidney disease (CKD) is one of the major
achievements of modern nephrology. Intensive research is now being undertaken to unravel …

Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

Most bodily functions vary over the course of a 24 h day. Circadian rhythms in body
temperature, sleep-wake cycles, metabolism, and blood pressure (BP) are just a few …

Highlights•Energy expenditure, substrate oxidation, and appetite follow circadian
rhythms.•Mistimed eating and sleeping disrupt circadian rhythms, increasing risk of …

Reports of sleep disturbances in attention deficit hyperactivity disorder (ADHD) are common
in both children and adults; however, the aetiology of such disturbances is poorly …

Modulation of basic biochemical and physiological processes by the circadian timing system
is now recognized as a fundamental feature of all mammalian organ systems. Within the …

The circadian clock exerts an important role in systemic homeostasis as it acts a keeper of
time for the organism. The synchrony between the daily challenges imposed by the …

Last year melatonin was 60 years old, or at least its discovery was 60 years ago. The
molecule itself may well be almost as old as life itself. So it is time to take yet another …