The endoplasmic reticulum (ER) functions as a quality-control organelle for protein
homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated …

Oxidative stress occurs through an imbalance between the generation of reactive oxygen
species (ROS) and the antioxidant defense mechanisms of cells. The eye is particularly …

Poor therapeutic outcomes of antioxidants in ophthalmologic clinical applications, including
glutathione during photoreceptor degeneration in retinitis pigmentosa (RP), are caused by …

Nanoscale extracellular vesicles (EVs), consisting of exomers, exosomes and microvesicles/
ectosomes, have been extensively investigated in the last 20 years, although their biological …

Retinitis pigmentosa, defined more properly as cone–rod dystrophy, is a paradigm of
inherited diffuse retinal dystrophies, one of the rare diseases with the highest prevalence in …

Mutations in the photoreceptor-specific C2orf71 gene (also known as photoreceptor cilium
actin regulator protein PCARE) cause autosomal recessive retinitis pigmentosa type 54 and …

Purpose To review the available evidence on the different retinal and visual prostheses for
patients with retinitis pigmentosa and new implants for other indications including dry age …

The human eye's intricate anatomical and physiological design necessitates tailored
approaches for managing ocular diseases. Recent advancements in ophthalmology …

Visual impairment and blindness are a growing public health problem as they reduce the life
quality of millions of people. The management and treatment of these diseases represent …

Owing to the promising therapeutic effect and one-time treatment advantage, gene therapy
may completely change the management of eye diseases, especially retinal diseases …