Genetic testing is used widely for diagnostic, carrier and predictive testing in monogenic
diseases. Until recently, there were no genetic testing options available for multifactorial …

Improvements in DNA sequencing technology and discoveries made by large scale genome-
wide association studies have led to enormous insight into the role of genetic variation in …

Polygenic risk scores (PRSs) for a variety of diseases have recently been shown to have
relative risks that depend on age, and genetic relative risks decrease with increasing age. A …

Background Many studies on prostate cancer (PCa) germline variants have been published
in the last 15 years. This review critically assesses their clinical validity and explores their …

The three most important recognized risks for prostate cancer (PCa) are increasing age,
ancestry, and family history of the disease. The clustering of PCa within families can be …

Objective There is no consensus on the role of biomarkers in determining the utility of
prostate biopsy in men with elevated prostate-specific antigen (PSA). There are numerous …

Background Type 2 diabetes mellitus (T2DM) is a prototypical complex disease with
polygenic architecture playing an important role in determining susceptibility to develop the …

Purpose: Family history of prostate cancer is one of the few universally accepted risk factors
for prostate cancer. How much an assessment of inherited polygenic risk for prostate cancer …

Background Polygenic risk score (PRS) has shown promise in predicting prostate cancer
(PCa) risk. However, the application of PRS in non‐European ancestry was poorly studied …

Background Significant racial disparities in prostate cancer incidence and mortality have
been reported between African American Men (AAM), who are at increased risk for prostate …