Exercise to Mitigate Cerebrovascular Aging: A Geroscience Perspective

AM Norling, LA Lipsitz - The Journals of Gerontology, Series A …, 2024 - academic.oup.com
Aging is characterized by a progressive loss of cellular functions that increase the risk of
developing chronic diseases, vascular dysfunction, and neurodegenerative conditions. The …

Pharmacological inhibition of ICOS attenuates the protective effect of exercise on cardiac fibrosis induced by isoproterenol

Y Peng, D Qin, Y Wang, W Gao, X Xu - European Journal of Pharmacology, 2024 - Elsevier
Aims To investigate the cardioprotective mechanism of exercise or exercise combined with
inducible costimulatory molecules (ICOS) monoclonal antibody (mAb) therapy against …

[HTML][HTML] Pathogenic mechanisms of cardiovascular damage in COVID-19

HH Shao, RX Yin - Molecular Medicine, 2024 - Springer
Background COVID-19 is a new infectious disease caused by the severe acute respiratory
syndrome coronavirus 2 (SARS CoV-2). Since the outbreak in December 2019, it has …

Mangiferin Alleviates Exercise‐Induced Fatigue through Inhibition of NFκB‐Mediated Inflammation and Oxidative Stress Based on Network Pharmacology

CJ Li, MT Li, YY Zhang, SF Xu, HX Li… - Journal of Food …, 2024 - Wiley Online Library
Background. Muscle fatigue is defined as a decrease in maximal force or power production
in response to contractile activity, which can cause muscle damage and limit athletic …

Physical activity, exercise and adverse cardiovascular outcomes in individuals with pre-existing cardiovascular disease: a narrative review

SK Kunutsor, JA Laukkanen - Expert Review of Cardiovascular …, 2024 - Taylor & Francis
Introduction The evidence supporting the cardiovascular health benefits of physical activity
and/or exercise training is well-established. While the role of physical activity in primary …

[HTML][HTML] Exercise and microbiome: From big data to therapy

D Meng, S Ai, M Spanos, X Shi, G Li, D Cretoiu… - Computational and …, 2023 - Elsevier
Exercise is a vital component in maintaining optimal health and serves as a prospective
therapeutic intervention for various diseases. The human microbiome, comprised of trillions …

[HTML][HTML] Engineering exosomes and their application in cardiovascular field: Bibliometric analysis from 2002 to 2022

X Zhang, Z Yang, J Jiang, M Tang, L Guan, H Lee… - Heliyon, 2023 - cell.com
Cardiovascular disease (CVD) is the leading cause of death around the world, warranting
an increasing number of studies for its treatment. Among all of its therapeutical strategies …

Inhibition of Hmbox1 Promotes Cardiomyocyte Survival and Glucose Metabolism Through Gck Activation in Ischemia/Reperfusion Injury

Y Bei, Y Zhu, J Zhou, S Ai, J Yao, M Yin, M Hu, W Qi… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: Exercise-induced physiological cardiac growth regulators may protect the
heart from ischemia/reperfusion (I/R) injury. Homeobox-containing 1 (Hmbox1), a homeobox …

[HTML][HTML] Aerobic interval training preconditioning protocols inhibit isoproterenol-induced pathological cardiac remodeling in rats: Implications on oxidative balance …

HS Bonab, JT Azar, H Soraya, AN Habashi - Sports Medicine and Health …, 2024 - Elsevier
This study aimed to investigate the potential cardioprotective effects of moderate and high-
intensity aerobic interval training (MIIT and HIIT) preconditioning. The focus was on …

[HTML][HTML] Exercise preconditioning inhibits doxorubicin-induced cardiotoxicity via YAP/STAT3 signaling

CZ Wang, HZ Guo, JZ Leng, ZD Liang, JT Wang… - Heliyon, 2024 - cell.com
Doxorubicin (DOX) possesses strong anti-tumor effects but is limited by its irreversible
cardiac toxicity. The relationship between exercise, a known enhancer of cardiovascular …