All methicillin resistant S. aureus (MRSA) strains carry an acquired genetic determinant–
mecA or mecC-which encode for a low affinity penicillin binding protein–PBP2A or PBP2A …

Bacterial toxins are virulence factors that manipulate host cell functions and take over the
control of vital processes of living organisms to favor microbial infection. Some toxins directly …

Background: Staphylococcus aureus is a major bacterial pathogen capable of causing a
range of infections in humans from gastrointestinal disease, skin and soft tissue infections, to …

Staphylococcus aureus is a Gram-positive pathogen capable of infecting nearly every
vertebrate organ. Among these tissues, invasive infection of bone (osteomyelitis) is …

Bacteria adapt efficiently to a wide range of nutritional environments. Therefore, they
possess overlapping regulatory systems that detect intracellular pools of key metabolites. In …

Dysfunction of phagocytes is a relevant risk factor for staphylococcal infection. The most
common hereditary phagocyte dysfunction is chronic granulomatous disease (CGD) …

Sepsis caused by Gram-positive bacterial pathogens is a major fatal disease but its
molecular basis remains elusive. Toll-like receptor 2 (TLR2) has been implicated in the …

The opportunistic pathogen Staphylococcus aureus is one of the major causes of health
care-associated infections. S. aureus is primarily an extracellular pathogen, but it was …

The stringent response is characterized by (p) ppGpp synthesis resulting in repression of
translation and reprogramming of the transcriptome. In Staphylococcus aureus,(p) ppGpp is …

The species-and clone-specific susceptibility of Staphylococcus cells for bacteriophages is
governed by the structures and glycosylation patterns of wall teichoic acid (WTA) …