Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …

Diacylglycerol (DAG) is a lipid second messenger that is generated in response to
extracellular stimuli and channels intracellular signals that affect mammalian cell …

Cancer invasion and metastasis are challenging to study in vivo since they occur deep
inside the body over extended time periods. Organotypic 3D culture of fresh tumor tissue …

Mammalian cell culture has provided the foundation for the incredible expansion of cell
biology to uncover the 'inner life of the cell'. The protocols for propagating cells in the …

Simple Summary Knowledge of the transcriptional regulation of breast cancer tumorigenesis
is largely based on studies performed in two-dimensional (2D) monolayer culture models …

The mechanical environment is important for tumorigenesis and progression. Tumor cells
can sense mechanical signals by mechanosensitive receptors, and these mechanical …

Thyroid hormone receptor interactor 12 (TRIP12) is an E3 ligase most notably involved in
the proteolytic degradation of the tumor suppressor p14ARF. Through this process, it is …

Recent evidence suggests that groups of cells are more likely to form clinically dangerous
metastatic tumors, emphasizing the importance of understanding mechanisms underlying …

The protein kinase D (PKD) family is a family of serine-threonine kinases that are members
of the calcium/calmodulin-dependent kinase (CaMK) superfamily. PKDs have been …

Cancer is a complex disease and it is now clear that not only epithelial tumor cells play a
role in carcinogenesis. The tumor microenvironment is composed of non-stromal cells …