2-Pyridone-containing heterocycles are considered privileged scaffolds in drug discovery
due to their behavior as hydrogen bond donors and/or acceptors and nonpeptidic mimics …

The azole antifungal drugs are an important class of chemotherapeutic agents with broad-
spectrum of activity against yeasts and filamentous fungi, act in the ergosterol biosynthetic …

Triazole is a very important scaffold in medicinal chemistry due to the wide spectrum of
biological activities and mainly antifungal activity of 1, 2, 4-triazole derivatives. The main …

Marine organisms including bacteria, fungi, algae, sponges, echinoderms, mollusks, and
cephalochordates produce a variety of products with antifungal activity including bacterial …

CYP51 is considered one of the most ancient P450 protein families. 1 It is perhaps the only
P450 protein family whose members are spread across all biological kingdoms, although it …

Background: Thiazole and benzothiazole derivatives, as well as thiazolidinones are very
important scaffolds in medicinal chemistry. Literature has revealed that they possess a wide …

Over the past decades, a tremendous rise in invasive fungal infection diseases attributed to
the yeast Candida albicans in immunocompromised individuals poses a seriously …

Background The purpose of this study was to unveil whether azole antifungals used in
agriculture, similar to the clinical azoles used in humans, can evoke resistance among …

Background: Bacterial infections are a growing problem worldwide causing morbidity and
mortality mainly in developing countries. Moreover, the increased number of …

The goal of this research is to investigate the antimicrobial activity of nineteen previously
synthesized 3, 6-disubstituted-1, 2, 4-triazolo [3, 4-b]-1, 3, 4-thiadiazole derivatives. The …