Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging

G David, S Mohammadi, AR Martin… - Nature Reviews …, 2019 - nature.com
Pathophysiological changes in the spinal cord white and grey matter resulting from injury
can be observed with MRI techniques. These techniques provide sensitive markers of …

MRI in traumatic spinal cord injury: from clinical assessment to neuroimaging biomarkers

P Freund, M Seif, N Weiskopf, K Friston… - The Lancet …, 2019 - thelancet.com
Traumatic spinal cord injury occurs when an external physical impact damages the spinal
cord and leads to permanent neurological dysfunction and disability, and it is associated …

[HTML][HTML] Dual-functional hydrogel system for spinal cord regeneration with sustained release of arylsulfatase B alleviates fibrotic microenvironment and promotes …

HH Park, YM Kim, HS Kim, SH Kim, X Jin, DH Hwang… - Biomaterials, 2022 - Elsevier
Traumatic damage to the spinal cord does not spontaneously heal, often leading to
permanent tissue defects. We have shown that injection of imidazole-poly …

Brain changes after spinal cord injury, a quantitative meta-analysis and review

LS Dahlberg, L Becerra, D Borsook… - … & Biobehavioral Reviews, 2018 - Elsevier
Abstract Spinal Cord Injuries (SCI) lead to alterations in brain structure and brain function by
direct effects of nerve damage, by secondary mechanisms, and also by longer term injury …

Guidelines for the conduct of clinical trials in spinal cord injury: Neuroimaging biomarkers

M Seif, CAM Gandini Wheeler-Kingshott… - Spinal Cord, 2019 - nature.com
Traumatic spinal cord injury (SCI) leads to immediate neuronal and axonal damage at the
focal injury site and triggers secondary pathologic series of events resulting in sensorimotor …

Dorsal and ventral horn atrophy is associated with clinical outcome after spinal cord injury

E Huber, G David, AJ Thompson, N Weiskopf… - Neurology, 2018 - AAN Enterprises
Objective To investigate whether gray matter pathology above the level of injury, alongside
white matter changes, also contributes to sensorimotor impairments after spinal cord injury …

Finger somatotopy is preserved after tetraplegia but deteriorates over time

S Kikkert, D Pfyffer, M Verling, P Freund, N Wenderoth - Elife, 2021 - elifesciences.org
Previous studies showed reorganised and/or altered activity in the primary sensorimotor
cortex after a spinal cord injury (SCI), suggested to reflect abnormal processing. However …

Spinal cord imaging markers and recovery of volitional leg movement with spinal cord epidural stimulation in individuals with clinically motor complete spinal cord …

E Rejc, AC Smith, KA Weber, B Ugiliweneza… - Frontiers in systems …, 2020 - frontiersin.org
Previous studies have shown that epidural stimulation of the lumbosacral spinal cord (scES)
can re-enable lower limb volitional motor control in individuals with chronic, clinically motor …

The damaged spinal cord is a suitable target for stem cell transplantation

A Curt, J Hsieh, M Schubert, M Hupp… - … and neural repair, 2020 - journals.sagepub.com
Background. Given individuals with spinal cord injury (SCI) approaching 2 million, viable
options for regenerative repair are desperately needed. Human central nervous system stem …

Predictive value of midsagittal tissue bridges on functional recovery after spinal cord injury

D Pfyffer, K Vallotton, A Curt… - … and neural repair, 2021 - journals.sagepub.com
Background The majority of patients with spinal cord injury (SCI) have anatomically
incomplete lesions and present with preserved tissue bridges, yet their outcomes vary …