Chemical insights into oxidative and nitrative modifications of DNA

CMC Andrés, JMP Lastra, CA Juan, FJ Plou… - International Journal of …, 2023 - mdpi.com
This review focuses on DNA damage caused by a variety of oxidizing, alkylating, and
nitrating species, and it may play an important role in the pathophysiology of inflammation …

Purinergic signaling in oral tissues

M Zuccarini, P Giuliani, M Ronci, F Caciagli… - International Journal of …, 2022 - mdpi.com
The role of the purinergic signal has been extensively investigated in many tissues and
related organs, including the central and peripheral nervous systems as well as the …

Spatially resolved molecular analysis of host response to medical device implantation using the 3D OrbiSIMS highlights a critical role for lipids

W Suvannapruk, LE Fisher, JC Luckett… - Advanced …, 2024 - Wiley Online Library
A key goal for implanted medical devices is that they do not elicit a detrimental immune
response. Macrophages play critical roles in the modulation of the host immune response …

Advancements in Analyzing Tumor Metabolites through Chemical Derivatization-Based Chromatography

L Ye, HM Zhang, BJ Zhou, W Tang, JL Zhou - Journal of Chromatography A, 2023 - Elsevier
Understanding the metabolic abnormalities of tumors is crucial for early diagnosis,
prognosis, and treatment. Accurate identification and quantification of metabolites in …

Hyperpolarizing DNA Nucleobases via NMR Signal Amplification by Reversible Exchange

BE Kidd, ME Gemeinhardt, JA Mashni, JL Gesiorski… - Molecules, 2023 - mdpi.com
The present work investigates the potential for enhancing the NMR signals of DNA
nucleobases by parahydrogen-based hyperpolarization. Signal amplification by reversible …

Periodic hypoxia, intermittent pain, and caffeine in male and female neonatal rats: corticosterone, insulin resistance, and hepatic gene expression

AL Gehrand, JM Phillips, H Raff - American Journal of …, 2023 - journals.physiology.org
Preterm infants experience multiple stressors including periodic neonatal hypoxia,
maternal/caregiver separation, and acute pain from clinical procedures. Although neonatal …

Characterisation of the modulation of immune response to polymer implants using established and novel methods

W Suvannapruk - 2023 - eprints.nottingham.ac.uk
As understanding of host immune responses towards implanted biomaterials has grown,
macrophages have been identified as critical predictors of inflammatory consequences …

Impact of exercise training on stress signaling pathway and purine metabolism in healthy and disease models and the influence of ribose supplementation

B Qi - 2023 - vuir.vu.edu.au
Regular exercise improves physical fitness and general health via significant muscle
molecular adaptations. ATP (energy) and its regulation is critical to metabolic homeostasis …