Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

Oxidative stress (OS) is primarily caused by the formation of free radicals and reactive
oxygen species; it is considered as one of the prominent factors in slowing down and …

Increased production and buildup of reactive oxygen species (ROS) can lead to various
health issues, including metabolic problems, cancers, and neurological conditions. Our …

Alterations of redox homeostasis leads to a condition of resilience known as hormesis that is
due to the activation of redox-sensitive pathways stimulating cell proliferation, growth …

In recent years, the role played by melatonin on the gut microbiota has gained increasingly
greater attention. Additionally, the gut microbiota has been proposed as an alternative …

Brain metabolism is comprised in Alzheimer's disease (AD) and Parkinson's disease (PD).
Since the brain primarily relies on metabolism of glucose, ketone bodies, and amino acids …

Mitochondrial dysfunction is a pathophysiological hallmark of most neurodegenerative
diseases. Several clinical trials targeting mitochondrial dysfunction have been performed …

Neurodegenerative diseases (NDDs) causing cognitive impairment and dementia are
difficult to treat due to the lack of understanding of primary initiating factors. Meanwhile …

Alzheimer's disease (AD) is a neurodegenerative disease of the central nervous system that
occurs in old age and pre-aging, characterized by progressive cognitive dysfunction and …

Mitochondrial dysfunction, oxidative stress, inflammation and glucose dysmetabolism are
pathological signs of Alzheimer's disease (AD). Dietary aluminum (Al) overload is often used …