Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …

Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson
disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis …

All eukaryotes rely on selective proteolysis to control the abundance of key regulatory
proteins and maintain a healthy and properly functioning proteome. Most of this turnover is …

The production of reactive species is an inevitable by-product of metabolism and thus, life
itself. Since reactive species are able to damage cellular structures, especially proteins, as …

The ubiquitin–proteasome system (UPS) is the major intracellular and non-lysosomal
protein degradation system. Thanks to its unique capacity of eliminating old, damaged …

The majority of critically ill intensive care unit (ICU) patients with severe sepsis develop ICU-
acquired weakness (ICUAW) characterized by loss of muscle mass, reduction in myofiber …

Intracellular protein synthesis, folding, and degradation are tightly controlled processes to
ensure proper protein homeostasis. The proteasome is responsible for the degradation of …

Type I interferonopathies cover a phenotypically heterogeneous group of rare genetic
diseases including the recently described proteasome-associated autoinflammatory …

The Ddi1/DDI2 proteins are ubiquitin shuttling factors, implicated in a variety of cellular
functions. In addition to ubiquitin-binding and ubiquitin-like domains, they contain a …

Immunoproteasome (IP) inhibition holds potential as a novel treatment option for various
immune-mediated pathologies. The IP inhibitor ONX 0914 reduced T cell cytokine secretion …