Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune
system and are the first line of host defense against microbial pathogens by recognizing …

Toll-like receptors (TLRs) respond to pathogen constituents, such as microbial lipids and
nucleic acids (NAs). TLRs recognize NAs in endosomal compartments. Structural and …

Objectives T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM)
domain (TIGIT) is a newly discovered immune checkpoint (IC) that exhibits …

Genetic and in vivo evidence suggests that aberrant recognition of RNA-containing
autoantigens by Toll-like receptors (TLRs) 7 and 8 drives autoimmune diseases. Here we …

Loss-of-function mutations in the lysosomal nucleoside transporter SLC29A3 cause
lysosomal nucleoside storage and histiocytosis: phagocyte accumulation in multiple organs …

Growth and differentiation factor 15 (GDF15), a divergent member of the transforming growth
factor-β superfamily, has been associated with acute and chronic inflammatory conditions …

Patients with STAT1 gain-of-function (GOF) mutations suffer from an inborn error of immunity
hallmarked by chronic mucocutaneous candidiasis (CMC). The pathogenesis behind this …

Inhibitory oligodeoxynucleotides (INH-ODN) can exert an immunomodulatory effect to
specifically block TLR7 and TLR9 signaling in systemic lupus erythematosus (SLE). To …

Evidence from animal models and human genetics implicates Toll-like Receptors (TLRs) in
the pathogenesis of Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA) …

Since the description of age-associated or autoimmune-associated B cells (ABCs), there has
been a growing interest in the role of these cells in autoimmunity. ABCs are differently …