Glycoconjugates: synthesis, functional studies, and therapeutic developments
Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …
Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke
C Yang, KE Hawkins, S Doré… - American Journal of …, 2019 - journals.physiology.org
As part of the neurovascular unit, the blood-brain barrier (BBB) is a unique, dynamic
regulatory boundary that limits and regulates the exchange of molecules, ions, and cells …
regulatory boundary that limits and regulates the exchange of molecules, ions, and cells …
Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood–brain barrier dysfunction module
Blood vessels in the CNS form a specialized and critical structure, the blood–brain barrier
(BBB). We present a resource to understand the molecular mechanisms that regulate BBB …
(BBB). We present a resource to understand the molecular mechanisms that regulate BBB …
[HTML][HTML] The blood-brain barrier in Alzheimer's disease
E Zenaro, G Piacentino, G Constantin - Neurobiology of disease, 2017 - Elsevier
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by the
pathological accumulation of amyloid beta (Aβ) peptides and neurofibrillary tangles …
pathological accumulation of amyloid beta (Aβ) peptides and neurofibrillary tangles …
[HTML][HTML] Brown algae carbohydrates: Structures, pharmaceutical properties, and research challenges
Y Li, Y Zheng, Y Zhang, Y Yang, P Wang, B Imre… - Marine drugs, 2021 - mdpi.com
Brown algae (Phaeophyceae) have been consumed by humans for hundreds of years.
Current studies have shown that brown algae are rich sources of bioactive compounds with …
Current studies have shown that brown algae are rich sources of bioactive compounds with …
[HTML][HTML] Physiologic events of embryo implantation and decidualization in human and non-human primates
MA Ochoa-Bernal, AT Fazleabas - International journal of molecular …, 2020 - mdpi.com
Reproduction is a fundamental process for the preservation of the human species. This
process requires a sequence of orchestrated events that are necessary for a successful …
process requires a sequence of orchestrated events that are necessary for a successful …
Mechanical forces in the immune system
M Huse - Nature Reviews Immunology, 2017 - nature.com
Leukocytes can completely reorganize their cytoskeletal architecture within minutes. This
structural plasticity, which facilitates their migration and communicative function, also …
structural plasticity, which facilitates their migration and communicative function, also …
Nanoparticles and targeted drug delivery in cancer therapy
B Bahrami, M Hojjat-Farsangi, H Mohammadi… - Immunology letters, 2017 - Elsevier
Surgery, chemotherapy, radiotherapy, and hormone therapy are the main common anti-
tumor therapeutic approaches. However, the non-specific targeting of cancer cells has made …
tumor therapeutic approaches. However, the non-specific targeting of cancer cells has made …
[HTML][HTML] Altered cell adhesion and glycosylation promote cancer immune suppression and metastasis
Cell-cell interactions and cell adhesion are key mediators of cancer progression and
facilitate hallmarks of cancer including immune evasion and metastatic dissemination. Many …
facilitate hallmarks of cancer including immune evasion and metastatic dissemination. Many …
Sialic acids in cancer biology and immunity
OMT Pearce, H Läubli - Glycobiology, 2016 - academic.oup.com
During malignant transformation, glycosylation is heavily altered compared with healthy
tissue due to differential expression of glycosyltransferases, glycosidases and …
tissue due to differential expression of glycosyltransferases, glycosidases and …