Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis,
autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by …

Progressive supranuclear palsy (PSP) is a complex clinicopathologic disease with no
current cure or disease modulating therapies that can only be definitively confirmed at …

Ferroptosis is an iron-dependent form of regulated cell death associated with uncontrolled
membrane lipid peroxidation and destruction. Previously, we showed that dietary dihomo …

Brains from persons with Alzheimer disease (AD) and its earlier stage, amnestic mild
cognitive impairment (MCI), exhibit high levels of oxidative damage, including that to …

Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of
progressive neurodegenerative diseases characterized by iron deposition in the globus …

Ageing, and particularly the onset of age-related diseases, is associated with tissue
dysfunction and macromolecular damage, some of which can be attributed to accumulation …

Damage accumulation in long-living macromolecules (especially extracellular matrix (ECM)
proteins, nuclear pore complex (NPC) proteins, and histones) is a missing hallmark of aging …

The effect of a reduced deuterium (D) content in the incubation medium on the survival of
cultured neurons in vitro and under glucose deprivation was studied. In addition, we studied …

This article presents the original descriptions of some recent physics mechanisms (based on
the thermodynamic, kinetic, and quantum tunnel effects) providing stable 2H/1H isotope …

Although the human lifespan has increased in the past century owing to advances in
medicine and lifestyle, the human healthspan has not kept up the same pace, especially in …