Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

Non-alcoholic fatty liver disease (NAFLD) is to date the most common chronic liver disease
in clinical practice and, consequently, a major health problem worldwide. It affects …

A bidirectional relationship exists between adipose tissue metabolism and iron regulation.
Total body fat, fat distribution and exercise influence iron status and components of the iron …

The mechanisms by which exercise benefits human health remain incompletely understood.
With the emergence of omics techniques, mapping of the molecular response to exercise is …

Mitokines are signaling molecules that enable communication of local mitochondrial stress
to other mitochondria in distant cells and tissues. Among those molecules are FGF21 …

Metabolic-associated fatty liver disease (MAFLD) is the most prevalent chronic liver disease
worldwide, affecting 25% of people globally and up to 80% of people with obesity. MAFLD is …

Comparing energy metabolism in human skeletal muscle and primary skeletal muscle cells
in obesity, while focusing on glucose and fatty acid metabolism, shows many common …

How exercise elicits systemic metabolic benefits in both muscles and non-contractile tissues
is unclear. Autophagy is a stress-induced lysosomal degradation pathway that mediates …

The skeletal muscle is the largest organ in the body and secretes circulating factors,
including myokines, which are involved in various cellular signaling processes. Skeletal …

Type 2 diabetes (T2D), one of the most prevalent noncommunicable diseases, is often
preceded by insulin resistance (IR), which underlies the inability of tissues to respond to …