Genetically engineered T cells are powerful new medicines, offering hope for curative
responses in patients with cancer. Chimaeric antigen receptors (CARs) are a class of …

Traditional cancer treatments use nonspecific drugs and monoclonal antibodies to target
tumor cells. Chimeric antigen receptor (CAR)-T cell therapy, however, leverages the immune …

Adoptive T cell transfer for cancer and chronic infection is an emerging field that shows
promise in recent trials. Synthetic-biology-based engineering of T lymphocytes to express …

Harnessing the immune system to eradicate malignant cells is becoming a most powerful
new approach to cancer therapy. FDA approval of the immunotherapy-based drugs …

We present a mathematical model of the cytotoxic T lymphocyte response to the growth of an
immunogenic tumor. The model exhibits a number of phenomena that are seen in vivo …

Adoptive immunotherapy with functional T cells is potentially an effective therapeutic
strategy for combating many types of cancer and viral infection. However, exhaustion of …

T cell-based adoptive immunotherapy has been shown to be a promising treatment for
various types of cancer. However, adoptive T cell therapy currently requires the custom …

The importance of CD4+ T cells in the induction of an optimal antitumor immune response
has largely been attributed to their ability to provide costimulatory signals for the priming of …

We developed an in vitro method for isolating and expanding autologous CD4+ T-cell
clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these …

This study shows that removal of a T cell subpopulation can evoke effective tumor immunity
in otherwise nonresponding animals. Elimination of CD25-expressing T cells, which …