Mutations and evolution of the SARS-CoV-2 spike protein
The SARS-CoV-2 spike protein mediates target recognition, cellular entry, and ultimately the
viral infection that leads to various levels of COVID-19 severities. Positive evolutionary …
viral infection that leads to various levels of COVID-19 severities. Positive evolutionary …
An overview on nanoparticle-based strategies to fight viral infections with a focus on COVID-19
S Yasamineh, HG Kalajahi, P Yasamineh… - Journal of …, 2022 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to COVID-19 and has
become a pandemic worldwide with mortality of millions. Nanotechnology can be used to …
become a pandemic worldwide with mortality of millions. Nanotechnology can be used to …
SARS-CoV-2 evolved variants optimize binding to cellular glycocalyx
Viral variants of concern continue to arise for SARS-CoV-2, potentially impacting both
methods for detection and mechanisms of action. Here, we investigate the effect of an …
methods for detection and mechanisms of action. Here, we investigate the effect of an …
High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike
Designing prefusion-stabilized SARS-CoV-2 spike is critical for the effectiveness of COVID-
19 vaccines. All COVID-19 vaccines in the US encode spike with K986P/V987P mutations to …
19 vaccines. All COVID-19 vaccines in the US encode spike with K986P/V987P mutations to …
Interaction of SARS-CoV-2 with host cells and antibodies: experiment and simulation
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …
Structural analysis of the Spike of the Omicron SARS-COV-2 variant by cryo-EM and implications for immune evasion
ABSTRACT The Omicron (B. 1.1. 529) SARS-COV-2 was reported on November 24, 2021
and declared a variant of concern a couple of days later., With its constellation of mutations …
and declared a variant of concern a couple of days later., With its constellation of mutations …
Inhibition of Cell Motility by Cell-Penetrating Dynamic Covalent Cascade Exchangers: Integrins Participate in Thiol-Mediated Uptake
Integrins are cell surface proteins responsible for cell motility. Inspired by the rich disulfide
exchange chemistry of integrins, we show here the inhibition of cell migration by cascade …
exchange chemistry of integrins, we show here the inhibition of cell migration by cascade …
Exploring the pH dependence of the SARS‐CoV‐2 complete fusion domain and the role of its unique structural features
D Birtles, AE Oh, J Lee - Protein Science, 2022 - Wiley Online Library
SARS‐CoV‐2 may enter target cells through the process of membrane fusion at either the
plasma (~ pH 7.4–7.0) or endosomal (~ pH 6.5–5.0) membrane in order to deliver its genetic …
plasma (~ pH 7.4–7.0) or endosomal (~ pH 6.5–5.0) membrane in order to deliver its genetic …
Intrinsically disordered proteins: Perspective on COVID-19 infection and drug discovery
R Tenchov, QA Zhou - ACS Infectious Diseases, 2022 - ACS Publications
Since the beginning of the COVID-19 pandemic caused by SARS-CoV-2, millions of patients
have been diagnosed and many of them have died from the disease worldwide. The …
have been diagnosed and many of them have died from the disease worldwide. The …
Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host …
Investigation of potential hosts of the severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) is crucial to understanding future risks of spillover and spillback. SARS-CoV …
(SARS-CoV-2) is crucial to understanding future risks of spillover and spillback. SARS-CoV …