Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

Lipids are crucial components of cellular function owing to their role in membrane formation,
intercellular signaling, energy storage, and homeostasis maintenance. In the brain, lipid …

Dementia is a rapidly rising global health crisis that silently disables families and ends lives
and livelihoods around the world. To date, however, no early biomarkers or effective …

Lipids, as the basic component of cell membranes, play an important role in human health
as well as brain function. The brain is highly enriched in lipids, and disruption of lipid …

Despite continuing debate about the amyloid β‐protein (or Aβ hypothesis, new lines of
evidence from laboratories and clinics worldwide support the concept that an imbalance …

Synapse loss in Alzheimer's disease (AD) correlates with cognitive decline. Involvement of
microglia and complement in AD has been attributed to neuroinflammation, prominent late in …

The past two decades of research into the pathogenesis of Alzheimer disease (AD) have
been driven largely by the amyloid hypothesis; the neuroinflammation that is associated with …

Alzheimer's disease (AD) is characterized by an imbalance between production and
clearance of amyloid-β (Aβ) species. Aβ peptides can transform structurally from monomers …

Extracellular vesicles, including exosomes and microvesicles, are small, nano-to-micrometer
vesicles that are released from cells. While initially observed in immune cells and …

Highlights•Recent GWAS identified microglia-related pathways as risk factors for
Alzheimer's.•Role of immune molecules in synapse loss, a hallmark of Alzheimer's, is poorly …