Metabolomics is an area of intriguing and growing interest. Since the late 1990s, when the
first Omic applications appeared to study metabolite's pool (“metabolome”), to understand …

The developments in mass spectrometry (MS) in the past few decades reveal the power and
versatility of this technology. MS methods are utilized in routine analyses as well as research …

Phosphorylated compounds and organic acids with multiple carboxylate groups are
commonly observed to have poor peak shapes and signal in LC/MS experiments. The poor …

Compounds derived from natural sources represent the majority of small-molecule drugs
utilized today. Plants, owing to their complex biosynthetic pathways, are poised to …

Mass spectral data sets often contain experimental artefacts, and data filtering prior to
statistical analysis is crucial to extract reliable information. This is particularly true in …

Introduction Metabolite annotation is a critical and challenging step in mass spectrometry-
based metabolomic profiling. In a typical untargeted MS/MS-based metabolomic study …

Nanoparticle-assisted laser desorption/ionization mass spectrometry (LDI-MS) is a powerful
tool for the analysis of a wide range of molecules. Many of the drawbacks in the matrix …

Untargeted metabolomics experiments usually rely on tandem mass spectrometry (MS/MS)
to identify the thousands of compounds in a complex sample. Spectral libraries used for …

Metabolomics is the systematic study of metabolite profiles of complex biological systems,
and involves the systematic identification and quantification of metabolites. Metabolism is …

The metabolic phenotype of an organism depends on a complex regulatory network, which
integrates the plethora of intrinsic and external information and prioritizes the flow of …