Clinical trials of stem cell treatment for spinal cord injury

K Yamazaki, M Kawabori, T Seki, K Houkin - International Journal of …, 2020 - mdpi.com
There are more than one million patients worldwide suffering paralysis caused by spinal
cord injury (SCI). SCI causes severe socioeconomic problems not only to the patients and …

Medical gas therapy for tissue, organ, and CNS protection: a systematic review of effects, mechanisms, and challenges

RD Zafonte, L Wang, CA Arbelaez… - Advanced …, 2022 - Wiley Online Library
Gaseous molecules have been increasingly explored for therapeutic development. Here,
following an analytical background introduction, a systematic review of medical gas …

[HTML][HTML] An NT-3-releasing bioscaffold supports the formation of TrkC-modified neural stem cell-derived neural network tissue with efficacy in repairing spinal cord …

G Li, B Zhang, J Sun, L Shi, M Huang, L Huang, Z Lin… - Bioactive materials, 2021 - Elsevier
The mechanism underlying neurogenesis during embryonic spinal cord development
involves a specific ligand/receptor interaction, which may be help guide neuroengineering to …

Neural stem cells overexpressing nerve growth factor improve functional recovery in rats following spinal cord injury via modulating microenvironment and enhancing …

L Wang, S Gu, J Gan, Y Tian, F Zhang… - Frontiers in Cellular …, 2021 - frontiersin.org
Spinal cord injury (SCI) is a devastating event characterized by severe motor, sensory, and
autonomic dysfunction. Currently, there is no effective treatment. Previous studies showed …

Mesenchymal stem cells as a multimodal treatment for nervous system diseases

B Badyra, M Sułkowski, O Milczarek… - Stem Cells …, 2020 - academic.oup.com
Neurological disorders are a massive challenge for modern medicine. Apart from the fact
that this group of diseases is the second leading cause of death worldwide, the majority of …

Effects of mesenchymal stem cell transplantation on spinal cord injury patients

F Tahmasebi, S Barati - Cell and Tissue Research, 2022 - Springer
Spinal cord injury (SCI) is a traumatic injury with sensory and motor deficits that more than 1
million patients worldwide suffer from disability due to it. Many pharmacological therapies …

Stem cell secretome for spinal cord repair: is it more than just a random baseline set of factors?

K Pajer, T Bellák, A Nógrádi - Cells, 2021 - mdpi.com
Hundreds of thousands of people suffer spinal cord injuries each year. The experimental
application of stem cells following spinal cord injury has opened a new era to promote …

The superiority of conditioned medium derived from rapidly expanded mesenchymal stem cells for neural repair

YT Chen, MJ Tsai, N Hsieh, MJ Lo, MJ Lee… - Stem Cell Research & …, 2019 - Springer
Abstracts Background Spinal cord injury (SCI) is a complex and severe neurological
condition. Mesenchymal stem cells (MSCs) and their secreted factors show promising …

Non-invasive approaches to functional recovery after spinal cord injury: Therapeutic targets and multimodal device interventions

C Pizzolato, MA Gunduz, D Palipana, J Wu… - Experimental …, 2021 - Elsevier
This paper is an interdisciplinary narrative review of efficacious non-invasive therapies that
are increasingly used to restore function in people with chronic spinal cord injuries (SCI) …

Neuromusculoskeletal modeling-based prostheses for recovery after spinal cord injury

C Pizzolato, DJ Saxby, D Palipana… - Frontiers in …, 2019 - frontiersin.org
Concurrent stimulation and reinforcement of motor and sensory pathways has been
proposed as an effective approach to restoring function after developmental or acquired …