Pathophysiology, diagnosis, and pharmacological treatment of prurigo nodularis

KA Williams, YS Roh, I Brown, N Sutaria… - Expert Review of …, 2021 - Taylor & Francis
Introduction: Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by
intensely pruritic, hyperkeratotic nodules distributed on the trunk and extensor surfaces of …

Clinical phenotypes of adult atopic dermatitis and related therapies

C Patruno, L Potestio, M Napolitano - Current Opinion in Allergy …, 2022 - journals.lww.com
Currently, the most relevant data are those for cyclosporine, alitretinoin, and dupilumab.
Cyclosporine and dupilumab showed to be effective in the treatment of atopic dermatitis …

Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials

G Yosipovitch, N Mollanazar, S Ständer, SG Kwatra… - Nature medicine, 2023 - nature.com
Prurigo nodularis (PN) is a chronic inflammatory skin disease with intensely pruritic nodules.
The LIBERTY-PN PRIME and PRIME2 phase 3 trials enrolled adults with PN with≥ 20 …

[HTML][HTML] Transcriptomic characterization of prurigo nodularis and the therapeutic response to nemolizumab

LC Tsoi, F Hacini-Rachinel, P Fogel… - Journal of Allergy and …, 2022 - Elsevier
Background Prurigo nodularis (PN) is a debilitating, difficult-to-treat, intensely pruritic,
chronic inflammatory skin disease characterized by hyperkeratotic skin nodules. The …

Prurigo nodularis is characterized by systemic and cutaneous T helper 22 immune polarization

M Belzberg, MP Alphonse, I Brown, KA Williams… - Journal of Investigative …, 2021 - Elsevier
Prurigo nodularis (PN) is an understudied, chronic inflammatory skin disease that
disproportionately affects African Americans and presents with intensely pruritic nodules of …

A polygenic risk score for predicting racial and genetic susceptibility to prurigo nodularis

C Vasavda, G Wan, MD Szeto, M Marani… - Journal of Investigative …, 2023 - Elsevier
Prurigo nodularis (PN) is an understudied inflammatory skin disease characterized by
pruritic, hyperkeratotic nodules. Identifying the genetic factors underlying PN could help to …

Clinical characteristics and disease burden in prurigo nodularis

P Aggarwal, J Choi, N Sutaria, YS Roh… - Clinical and …, 2021 - academic.oup.com
Background Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by
intense pruritus, but information on patient experience and impact on quality of life (QoL) …

Modulation of neuroimmune and epithelial dysregulation in patients with moderate to severe prurigo nodularis treated with nemolizumab

J Deng, V Liao, V Parthasarathy, HL Cornman… - JAMA …, 2023 - jamanetwork.com
Importance Prurigo nodularis (PN) is a debilitating skin disease characterized by intense
pruritus and hyperkeratotic skin nodules. Nemolizumab, a monoclonal antibody targeting …

Chronic prurigo including prurigo nodularis: new insights and treatments

S Müller, C Zeidler, S Ständer - American Journal of Clinical Dermatology, 2024 - Springer
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the
presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated …

Health-related quality of life and economic burden of prurigo nodularis

KA Whang, TK Le, R Khanna, KA Williams… - Journal of the American …, 2022 - Elsevier
Background Prurigo nodularis (PN) is an understudied, pruritic inflammatory skin disease.
Little is known about the effect of PN on quality of life and its associated economic burden …