[HTML][HTML] Hyaluronic Acid: A Powerful Biomolecule with Wide-Ranging Applications—A Comprehensive Review

GN Iaconisi, P Lunetti, N Gallo, AR Cappello… - International Journal of …, 2023 - mdpi.com
Hyaluronic acid (HA) is a glycosaminoglycan widely distributed in the human body,
especially in body fluids and the extracellular matrix of tissues. It plays a crucial role not only …

Arachidonic acid metabolism in health and disease

Y Zhang, Y Liu, J Sun, W Zhang, Z Guo, Q Ma - MedComm, 2023 - Wiley Online Library
Arachidonic acid (AA), an n‐6 essential fatty acid, is a major component of mammalian cells
and can be released by phospholipase A2. Accumulating evidence indicates that AA plays …

[HTML][HTML] An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment

G Li, S Liu, Y Chen, J Zhao, H Xu, J Weng, F Yu… - Nature …, 2023 - nature.com
Intra-articular injection of therapeutics is an effective strategy for treating osteoarthritis (OA),
but it is hindered by rapid drug diffusion, thereby necessitating high-frequency injections …

Engineered MgO nanoparticles for cartilage-bone synergistic therapy

L Zheng, S Zhao, Y Li, J Xu, W Yan, B Guo, J Xu… - Science …, 2024 - science.org
The emerging therapeutic strategies for osteoarthritis (OA) are shifting toward
comprehensive approaches that target periarticular tissues, involving both cartilage and …

[HTML][HTML] Connection between osteoarthritis and nitric oxide: from pathophysiology to therapeutic target

H Jiang, P Ji, X Shang, Y Zhou - Molecules, 2023 - mdpi.com
Osteoarthritis (OA), a disabling joint inflammatory disease, is characterized by the
progressive destruction of cartilage, subchondral bone remodeling, and chronic synovitis …

[HTML][HTML] Efficacy and safety of gutong patch compared with nsaids for knee osteoarthritis: a real-world multicenter, prospective cohort study in China

Y Wang, D Li, Z Lv, B Feng, T Li, X Weng - Pharmacological Research, 2023 - Elsevier
Abstract The Gutong Patch (GTP) is common in clinical practice for bone diseases. This
study compared the efficacy and safety of GTP and nonsteroidal anti-inflammatory drugs …

[HTML][HTML] Effect of intra-articular injection of a hyaluronic acid-alendronate conjugate on post-traumatic osteoarthritis induced by destabilization of the medial meniscus …

A Scanu, R Luisetto, M Pavan, C Guarise… - Scientific Reports, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by pain and
cartilage damage. Intra-articular (ia) viscosupplementation with hyaluronic acid (HA) is …

[HTML][HTML] Radiographic Biomarkers for Knee Osteoarthritis: A Narrative Review

A Almhdie-Imjabbar, H Toumi, E Lespessailles - Life, 2023 - mdpi.com
Conventional radiography remains the most widely available imaging modality in clinical
practice in knee osteoarthritis. Recent research has been carried out to develop novel …

[HTML][HTML] MiR-146b-5p enriched bioinspired exosomes derived from fucoidan-directed induction mesenchymal stem cells protect chondrocytes in osteoarthritis by …

C Lou, H Jiang, Z Lin, T Xia, W Wang, C Lin… - Journal of …, 2023 - Springer
Osteoarthritis (OA) is a common degenerative joint disease characterized by progressive
cartilage degradation and inflammation. In recent years, mesenchymal stem cells (MSCs) …

New treatment for osteoarthritis: Gene therapy

X Li, L Shen, Z Deng, Z Huang - Precision Clinical Medicine, 2023 - academic.oup.com
Osteoarthritis is a complex degenerative disease that affects the entire joint tissue. Currently,
non-surgical treatments for osteoarthritis focus on relieving pain. While end-stage …