GABA A receptors are pentameric ligand-gated ion channels that mediate most fast
neuronal inhibition in the brain. In addition to their important physiological roles, they are …

The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …

Most general anaesthetics and classical benzodiazepine drugs act through positive
modulation of γ-aminobutyric acid type A (GABAA) receptors to dampen neuronal activity in …

Inhaled anesthetics are a chemically diverse collection of hydrophobic molecules that
robustly activate TWIK-related K+ channels (TREK-1) and reversibly induce loss of …

Although general anaesthesia has been of tremendous importance for the development of
surgery, the underlying mechanisms by which this state is achieved are only just beginning …

This review focuses on the unique clinical and molecular pharmacologic features of
etomidate. Among general anesthesia induction drugs, etomidate is the only imidazole, and …

Urethane is widely used as an anesthetic for animal studies because of its minimal effects
on cardiovascular and respiratory systems and maintenance of spinal reflexes. Despite its …

We investigated the role of regionally discrete GABA (γ-aminobutyric acid) receptors in the
sedative response to pharmacological agents that act on GABAA receptors (muscimol …

General anesthetics are widely used in clinical practice. On the molecular level, these
compounds have been shown to modulate the activity of various neuronal ion channels …

General anesthetics are essential to modern medicine, and yet a detailed understanding of
their mechanisms of action is lacking. General anesthetics were once believed to be 'drugs …