T lymphocytes with rxf3 receptors recognize antigen in association with the polymorphic
products of the class I and class II loci of the major histocompatibility complex (MHC). This …

Transmembrane (TM) helices of integral membrane proteins can facilitate strong and
specific noncovalent protein–protein interactions. Mutagenesis and structural analyses have …

Abstract The CLAVATA2 (CLV2) gene regulates both meristem and organ development in
Arabidopsis. We isolated the CLV2 gene and found that it encodes a receptor-like protein …

Staphylococcal protein A is anchored to the cell wall, a unique cellular compartment of Gram‐
positive bacteria. The sorting signal sufficient for cell wall anchoring consists of an LPXTG …

Revised Manuscript Received October 27, 1992 abstract: While several reports have
suggested a role for helix-helix interactions in membrane protein oligomerization, there are …

The astacin family of metalloendopeptidases was recognized as a novel family of proteases
in the 1990s. The crayfish enzyme astacin was the first characterized and is one of the …

▪ Abstract T cells constantly sample their environment using receptors (TCR) that possess
both a germline-encoded low affinity for major histocompatibility complex (MHC) molecules …

Voltage-dependent Ca 2+ channels are modulated by complex interactions with the α 2 δ
subunit. In vitro translation was used to demonstrate a single transmembrane topology of the …

Specific helix–helix interactions inside lipid bilayers guide the folding and assembly of many
integral membrane proteins and their complexes. We report here a pattern of 7 amino acids …

We used gene targeting techniques to produce mice lacking the invariant chain associated
with major histocompatibility complex (MHC) class II molecules. Cells from these mice show …