Tumor-infiltrating lymphocytes in the immunotherapy era
ST Paijens, A Vledder, M de Bruyn… - Cellular & molecular …, 2021 - nature.com
The clinical success of cancer immune checkpoint blockade (ICB) has refocused attention
on tumor-infiltrating lymphocytes (TILs) across cancer types. The outcome of immune …
on tumor-infiltrating lymphocytes (TILs) across cancer types. The outcome of immune …
Activation or exhaustion of CD8+ T cells in patients with COVID-19
In addition to CD4+ T cells and neutralizing antibodies, CD8+ T cells contribute to protective
immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID …
immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID …
BNT162b2 vaccination induces durable SARS-CoV-2–specific T cells with a stem cell memory phenotype
G Guerrera, M Picozza, S D'Orso, R Placido… - Science …, 2021 - science.org
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
effective in preventing hospitalization from severe COVID-19. However, multiple reports of …
effective in preventing hospitalization from severe COVID-19. However, multiple reports of …
CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome
S Arcangeli, C Bove, C Mezzanotte… - The Journal of …, 2022 - Am Soc Clin Investig
Chimeric antigen receptor (CAR) T cell expansion and persistence represent key factors to
achieve complete responses and prevent relapses. These features are typical of early …
achieve complete responses and prevent relapses. These features are typical of early …
SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells
JH Jung, MS Rha, M Sa, HK Choi, JH Jeon… - Nature …, 2021 - nature.com
Memory T cells contribute to rapid viral clearance during re-infection, but the longevity and
differentiation of SARS-CoV-2-specific memory T cells remain unclear. Here we conduct ex …
differentiation of SARS-CoV-2-specific memory T cells remain unclear. Here we conduct ex …
Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages
How the innate and adaptive host immune system miscommunicate to worsen COVID-19
immunopathology has not been fully elucidated. Here, we perform single-cell deep-immune …
immunopathology has not been fully elucidated. Here, we perform single-cell deep-immune …
From chemotherapy to biological therapy: A review of novel concepts to reduce the side effects of systemic cancer treatment
V Schirrmacher - International journal of oncology, 2019 - spandidos-publications.com
The side effects of systemic chemotherapy used to treat cancer are often severe. For
decades, oncologists have focused on treating the tumor, which may result in damage to the …
decades, oncologists have focused on treating the tumor, which may result in damage to the …
B cell maturation antigen–specific CAR T cells are clinically active in multiple myeloma
AD Cohen, AL Garfall, EA Stadtmauer… - The Journal of …, 2019 - Am Soc Clin Investig
BACKGROUND. CAR T cells are a promising therapy for hematologic malignancies. B cell
maturation antigen (BCMA) is a rational target in multiple myeloma (MM). METHODS. We …
maturation antigen (BCMA) is a rational target in multiple myeloma (MM). METHODS. We …
An engineered IL-2 partial agonist promotes CD8+ T cell stemness
Adoptive transfer of antigen-specific T cells represents a major advance in cancer
immunotherapy, with robust clinical outcomes in some patients. Both the number of …
immunotherapy, with robust clinical outcomes in some patients. Both the number of …
[HTML][HTML] CAR T cells for solid tumors: new strategies for finding, infiltrating, and surviving in the tumor microenvironment
M Martinez, EK Moon - Frontiers in immunology, 2019 - frontiersin.org
Chimeric antigen receptor (CAR) T cells, T cells that have been genetically engineered to
express a receptor that recognizes a specific antigen, have given rise to breakthroughs in …
express a receptor that recognizes a specific antigen, have given rise to breakthroughs in …