Recent progress in scientific and clinical research has made gene therapy a promising
option for efficient and targeted treatment of several inherited and acquired disorders. One of …

Several methods are available for non-invasive imaging of gene delivery and transgene
expression, including magnetic resonance imaging (MRI), single photon emission …

As the interest in gene therapy increases, the development of an efficient and reliable
means to monitor gene delivery and expression in patients is becoming more important. An …

Longitudinal and transverse rotating‐frame relaxation time constants, T1ρ and T2ρ, have
previously been successfully applied to detect gene therapy responses and acute stroke in …

Gene-directed enzyme prodrug therapy offers a new approach to treating some cancers.
Clinical trials have been completed for brain and prostate cancers and the first product for …

In the past decade, gene-and cell-based therapies have been translated into clinical
application despite enormous costs for the establishment of an efficient gene therapeutic …

Hyperpolarised [1‐13C] pyruvate MRI has shown promise in monitoring therapeutic efficacy
in a number of cancers including glioma. In this study, we assessed the pyruvate response …

Over the past ten years, a variety of imaging techniques have been developed that allow
non-invasive detection of gene expression within the brain of intact mammals, ranging from …

A deeper understanding of the role of specific genes, proteins, pathways and networks in
health and disease, coupled with the development of technologies to assay these molecules …

Gene therapy is a very attractive strategy in experimental cancer therapy. Ideally, the
approach aims to deliver therapeutic genes selectively to cancer cells. However, progress in …