New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN
A Monteil, NC Guérineau, A Gil-Nagel… - Physiological …, 2024 - journals.physiology.org
Cell excitability and its modulation by hormones and neurotransmitters involve the concerted
action of a large repertoire of membrane proteins, especially ion channels. Unique …
action of a large repertoire of membrane proteins, especially ion channels. Unique …
[HTML][HTML] The emerging role of the KCTD proteins in cancer
A Angrisani, A Di Fiore, E De Smaele… - Cell Communication and …, 2021 - Springer
The human family of Potassium (K+) Channel Tetramerization Domain (KCTD) proteins
counts 25 members, and a significant number of them are still only partially characterized …
counts 25 members, and a significant number of them are still only partially characterized …
[HTML][HTML] A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic …
C Wu, ZH Huang, ZQ Meng, XT Fan, S Lu, YY Tan… - Chinese Medicine, 2021 - Springer
Background Compound kushen injection (CKI), a Chinese patent drug, is widely used in the
treatment of various cancers, especially neoplasms of the digestive system. However, the …
treatment of various cancers, especially neoplasms of the digestive system. However, the …
Recent advances in understanding the molecular role of phosphoinositide-specific phospholipase C gamma 1 as an emerging onco-driver and novel therapeutic …
Phosphoinositide metabolism is crucial intracellular signaling system that regulates a
plethora of biological functions including mitogenesis, cell proliferation and division …
plethora of biological functions including mitogenesis, cell proliferation and division …
Systems pharmacodynamic model of combined gemcitabine and trabectedin in pancreatic cancer cells. Part I. Çô Effects on signal transduction pathways related to …
Pancreatic ductal adenocarcinoma (PDAC) is often chemotherapy-resistant, and novel drug
combinations would fill an unmet clinical need. Previously we reported synergistic cytotoxic …
combinations would fill an unmet clinical need. Previously we reported synergistic cytotoxic …
[HTML][HTML] Identification of key genes and pathways in pancreatic cancer gene expression profile by integrative analysis
W Lu, N Li, F Liao - Genes, 2019 - mdpi.com
Background: Pancreatic cancer is one of the malignant tumors that threaten human health.
Methods: The gene expression profiles of GSE15471, GSE19650, GSE32676 and …
Methods: The gene expression profiles of GSE15471, GSE19650, GSE32676 and …
Utilizing quantitative proteomics to identify species-specific protein therapeutic targets for the treatment of Leishmaniasis
S Krobthong, Y Yingchutrakul, P Samutrtai… - ACS …, 2022 - ACS Publications
Leishmaniasis is a tropical disease caused by Leishmania parasites, which are transmitted
through the bites of infected sandflies. We focused on the emergence of leishmaniasis in …
through the bites of infected sandflies. We focused on the emergence of leishmaniasis in …
[HTML][HTML] LncRNA DPP10-AS1 promotes malignant processes through epigenetically activating its cognate gene DPP10 and predicts poor prognosis in lung cancer …
H Tian, J Pan, S Fang, C Zhou, H Tian… - Cancer Biology & …, 2021 - ncbi.nlm.nih.gov
Objective: The purpose of this study was to explore the function and gene expression
regulation of the newly identified lncRNA DPP10-AS1 in lung cancer, and its potential value …
regulation of the newly identified lncRNA DPP10-AS1 in lung cancer, and its potential value …
[HTML][HTML] In silico analysis of gene expression change associated with copy number of enhancers in pancreatic adenocarcinoma
Understanding the gene regulatory network governing cancer initiation and progression is
necessary, although it remains largely unexplored. Enhancer elements represent the center …
necessary, although it remains largely unexplored. Enhancer elements represent the center …
[HTML][HTML] NMFNA: a non-negative matrix factorization network analysis method for identifying modules and characteristic genes of pancreatic cancer
Q Ding, Y Sun, J Shang, F Li, Y Zhang, JX Liu - Frontiers in Genetics, 2021 - frontiersin.org
Pancreatic cancer (PC) is a highly fatal disease, yet its causes remain unclear.
Comprehensive analysis of different types of PC genetic data plays a crucial role in …
Comprehensive analysis of different types of PC genetic data plays a crucial role in …