Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …

Chronic pain remains to be a clinical challenge and is recognized as a major health problem
with varying impacts on quality of life. Currently, the first-line therapy for chronic pain is …

Abnormalities in neocortical and synaptic development are linked to neurodevelopmental
disorders. However, the molecular and cellular mechanisms governing initial synapse …

Background Schizophrenia is a severe mental illness afflicting young adults just as they
approach their full potential, often resulting in a lifetime of severe disability. While many …

During development of the human cerebral cortex, multipotent neural progenitors generate
excitatory neurons and glial cells. Investigations of the transcriptome and epigenome have …

Translation modulates the timing and amplification of gene expression after transcription.
Brain development requires uniquely complex gene expression patterns, but large-scale …

The role of miRNAs in determining human neural stem cell (NSC) fate remains elusive
despite their high expression in the developing nervous system. In this study, we investigate …

Highlights•Neural progenitors are transcriptionally primed to generate diverse cortical cell
types.•Post-transcriptional control of progenitors and neurons fine tunes cell fate …

Historically, the mammalian brain was thought to lack stem cells as no new neurons were
found to be made in adulthood. That dogma changed∼ 25 years ago with the identification …

Efficacious stem cell-based therapies for traumatic brain injury (TBI) depend on successful
delivery, migration, and engraftment of stem cells to induce neuroprotection. L-myc …