Pyroptosis is a lytic and inflammatory type of programmed cell death that is usually triggered
by inflammasomes and executed by gasdermin proteins. The main characteristics of …

Cardiovascular diseases, the notorious killer, are mainly caused by atherosclerosis (AS)
characterized by lipids, cholesterol, and iron overload in plaques. Macrophages are effector …

Excess accumulation of mitochondrial reactive oxygen species (mtROS) is a key target for
inhibiting pyroptosis‐induced inflammation and tissue damage. However, targeted delivery …

Hyperuricemia closely correlates with the development of atherosclerosis, but little is known
of the mechanism by which atherosclerosis progression occurs in hyperuricemia …

Programmed cell deaths are pathways involving cells playing an active role in their own
destruction. Depending on the signaling system of the process, programmed cell death can …

Background Myocardial reperfusion injury is often accompanied by cell death and
inflammatory reactions. Recently, pyroptosis is gradually recognized as pivotal role in …

Ethnopharmacologic relevance Licorice is a traditional Chinese medicine that has been
used for cardiovascular diseases. Recent studies found that supplementation with licorice …

The overuse of acetaminophen (APAP) may cause more severe hepatotoxicity in patients
with non-alcoholic fatty liver disease (NAFLD). Caveolin-1 (CAV1), is an essential regulator …

Mounting evidence demonstrates uncontrolled endoplasmic reticulum (ER) stress
responses can activate the inflammasome, which generally results in endothelial …

Pyroptosis is a proinflammatory form of programmed cell death in response to inflammation.
It involves in the pathogenesis and outcomes of atherosclerosis characterized by NLRP3 …