Roles of host proteases in the entry of SARS-CoV-2
A Zabiegala, Y Kim, KO Chang - Animal Diseases, 2023 - Springer
The spike protein (S) of SARS-CoV-2 is responsible for viral attachment and entry, thus a
major factor for host susceptibility, tissue tropism, virulence and pathogenicity. The S is …
major factor for host susceptibility, tissue tropism, virulence and pathogenicity. The S is …
Cathepsins and SARS‐CoV‐2 infection: From pathogenic factors to potential therapeutic targets
S Zhao, M Jiang, H Qing, J Ni - British Journal of Pharmacology, 2023 - Wiley Online Library
Abstract Coronavirus disease‐19 (COVID‐19) is caused by severe acute respiratory
syndrome‐coronavirus‐2 (SARS‐CoV‐2) infection. The COVID‐19 pandemic began in …
syndrome‐coronavirus‐2 (SARS‐CoV‐2) infection. The COVID‐19 pandemic began in …
Potent 3CLpro inhibitors effective against SARS-CoV-2 and MERS-CoV in animal models by therapeutic treatment
P Li, Y Kim, CS Dampalla, H Nhat Nguyen… - Mbio, 2024 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Middle East
respiratory syndrome coronavirus (MERS-CoV) are zoonotic betacoronaviruses that …
respiratory syndrome coronavirus (MERS-CoV) are zoonotic betacoronaviruses that …
The HN protein of Newcastle disease virus induces cell apoptosis through the induction of lysosomal membrane permeabilization
Y Chen, S Zhu, T Liao, C Wang, J Han, Z Yang… - Plos …, 2024 - journals.plos.org
Lysosomes are acidic organelles that mediate the degradation and recycling of cellular
waste materials. Damage to lysosomes can cause lysosomal membrane permeabilization …
waste materials. Damage to lysosomes can cause lysosomal membrane permeabilization …
Evaluating Z-FA-FMK, a host cathepsin L protease inhibitor, as a potent and broad-spectrum antiviral therapy against SARS-CoV-2 and related coronaviruses
JH Jeong, JH Choi, BK Kim, SC Min, S Chokkakula… - Antiviral Research, 2023 - Elsevier
Abstract Even though the World Health Organization announced the end of the COVID-19
pandemic as a global public health emergency on May 5, 2023, SARS-CoV-2 continues to …
pandemic as a global public health emergency on May 5, 2023, SARS-CoV-2 continues to …
Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity
P Flury, J Breidenbach, N Krüger… - ACS Pharmacology & …, 2024 - ACS Publications
Cathepsins (Cats) are proteases that mediate the successful entry of SARS-CoV-2 into host
cells. We designed and synthesized a tailored series of 21 peptidomimetics and evaluated …
cells. We designed and synthesized a tailored series of 21 peptidomimetics and evaluated …
Eat, prey, love: Pathogen-mediated subversion of lysosomal biology
Highlights•Pathogens utilise varied and complex strategies to evade lysosomal
degradation.•Pathogen modulation of transcription factor EB (TFEB) is dynamic and …
degradation.•Pathogen modulation of transcription factor EB (TFEB) is dynamic and …
An Aptamer-Based Proteomic Analysis of Plasma from Cats (Felis catus) with Clinical Feline Infectious Peritonitis
Feline infectious peritonitis (FIP) is a systemic disease manifestation of feline coronavirus
(FCoV) and is the most important cause of infectious disease-related deaths in domestic …
(FCoV) and is the most important cause of infectious disease-related deaths in domestic …
A Review of the Antimicrobial Properties of Cyanobacterial Natural Products
IE Cock, MJ Cheesman - Molecules, 2023 - mdpi.com
The development of multiple-drug-resistant pathogens has prompted medical research
toward the development of new and effective antimicrobial therapies. Much research into …
toward the development of new and effective antimicrobial therapies. Much research into …
Host Cell Proteases Involved in Human Respiratory Viral Infections and Their Inhibitors: A Review
B Lubinski, GR Whittaker - Viruses, 2024 - mdpi.com
Viral tropism is most commonly linked to receptor use, but host cell protease use can be a
notable factor in susceptibility to infection. Here we review the use of host cell proteases by …
notable factor in susceptibility to infection. Here we review the use of host cell proteases by …