Mouse models of sarcopenia: classification and evaluation

W Xie, M He, D Yu, Y Wu, X Wang, S Lv… - Journal of cachexia …, 2021 - Wiley Online Library
Sarcopenia is a progressive and widespread skeletal muscle disease that is related to an
increased possibility of adverse consequences such as falls, fractures, physical disabilities …

Lipid modulation of skeletal muscle mass and function

C Lipina, HS Hundal - Journal of cachexia, sarcopenia and …, 2017 - Wiley Online Library
Loss of skeletal muscle mass is a characteristic feature of various pathologies including
cancer, diabetes, and obesity, as well as being a general feature of ageing. However, the …

[HTML][HTML] Prevalence and mechanisms of skeletal muscle atrophy in metabolic conditions

L Jun, M Robinson, T Geetha, TL Broderick… - International Journal of …, 2023 - mdpi.com
Skeletal muscle atrophy is prevalent in a myriad of pathological conditions, such as
diabetes, denervation, long-term immobility, malnutrition, sarcopenia, obesity, Alzheimer's …

High fat diet‐induced skeletal muscle wasting is decreased by mesenchymal stem cells administration: implications on oxidative stress, ubiquitin proteasome pathway …

J Abrigo, JC Rivera, J Aravena… - Oxidative medicine …, 2016 - Wiley Online Library
Obesity can lead to skeletal muscle atrophy, a pathological condition characterized by the
loss of strength and muscle mass. A feature of muscle atrophy is a decrease of myofibrillar …

Dietary l-carnitine supplementation recovers the increased pH and hardness in fillets caused by high-fat diet in Nile tilapia (Oreochromis niloticus)

ZY Zhang, SM Limbu, SH Zhao, LQ Chen, Y Luo… - Food Chemistry, 2022 - Elsevier
The wide use of high-fat diet (HFD) causes negative effects on flesh quality in farmed fish. l-
carnitine, a lipid-lowering additive, enhances mitochondrial fatty acid β-oxidation. However …

A chronic high-fat diet exacerbates contractile dysfunction with impaired intracellular Ca2+ release capacity in the skeletal muscle of aged mice

H Eshima, Y Tamura, S Kakehi… - Journal of Applied …, 2020 - journals.physiology.org
Obesity and aging reduce skeletal muscle contractile function. However, it remains unclear
whether obesity additively promotes muscle contractile dysfunction in the setting of aging. In …

[HTML][HTML] A skeletal muscle-centric view on time-restricted feeding and obesity under various metabolic challenges in humans and animals

C Livelo, Y Guo, GC Melkani - International Journal of Molecular Sciences, 2022 - mdpi.com
Nearly 50% of adults will suffer from obesity in the US by 2030. High obesity rates can lead
to high economic and healthcare burdens in addition to elevated mortality rates and reduced …

[HTML][HTML] Altered lipid metabolism impairs skeletal muscle force in young rats submitted to a short-term high-fat diet

DE Andrich, Y Ou, L Melbouci… - Frontiers in …, 2018 - frontiersin.org
Obesity and ensuing disorders are increasingly prevalent in young populations. Prolonged
exposure to high-fat diets (HFD) and excessive lipid accumulation were recently suggested …

[HTML][HTML] The imprinted gene Delta like non-canonical notch ligand 1 (Dlk1) associates with obesity and triggers insulin resistance through inhibition of skeletal muscle …

CH Jensen, M Rydén, C Baun, S Hvidsten… - …, 2019 - thelancet.com
Abstract Background The imprinted gene Delta like non-canonical Notch ligand 1 (Dlk1) is
considered an inhibitor of adipogenesis, but its in vivo impact on fat mass indeed remains …

High‐fat high‐sucrose diet leads to dynamic structural and inflammatory alterations in the rat vastus lateralis muscle

KH Collins, DA Hart, RA Reimer… - Journal of …, 2016 - Wiley Online Library
The influence of obesity on muscle integrity is not well understood. The purpose of this study
was to quantify structural and molecular changes in the rat vastus lateralis (VL) muscle as a …