[HTML][HTML] The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programmes. Significant advances have been made in understanding the …
expression programmes. Significant advances have been made in understanding the …
The evolving metabolic landscape of chromatin biology and epigenetics
Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …
inputs—which include both nutrient availability as a result of diet and growth factor signalling …
m6A RNA methyltransferases METTL3/14 regulate immune responses to anti‐PD‐1 therapy
An impressive clinical success has been observed in treating a variety of cancers using
immunotherapy with programmed cell death‐1 (PD‐1) checkpoint blockade. However …
immunotherapy with programmed cell death‐1 (PD‐1) checkpoint blockade. However …
[HTML][HTML] Mechanisms and functions of long non-coding RNAs at multiple regulatory levels
X Zhang, W Wang, W Zhu, J Dong, Y Cheng… - International journal of …, 2019 - mdpi.com
Long non-coding (lnc) RNAs are non-coding RNAs longer than 200 nt. lncRNAs primarily
interact with mRNA, DNA, protein, and miRNA and consequently regulate gene expression …
interact with mRNA, DNA, protein, and miRNA and consequently regulate gene expression …
[HTML][HTML] Mitochondria as signaling organelles control mammalian stem cell fate
RP Chakrabarty, NS Chandel - Cell stem cell, 2021 - cell.com
Recent evidence supports the notion that mitochondrial metabolism is necessary for the
determination of stem cell fate. Historically, mitochondrial metabolism is linked to the …
determination of stem cell fate. Historically, mitochondrial metabolism is linked to the …
[HTML][HTML] The role of m6A RNA methylation in cancer
T Sun, R Wu, L Ming - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Abstract N6-methyladenosine (m6A), the most abundant internal modification of RNA in
eukaryotic cells, has gained increasing attention in recent years. The m6A modification …
eukaryotic cells, has gained increasing attention in recent years. The m6A modification …
[HTML][HTML] m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade
Melanoma is one of the most deadly and therapy-resistant cancers. Here we show that N6-
methyladenosine (m6A) mRNA demethylation by fat mass and obesity-associated protein …
methyladenosine (m6A) mRNA demethylation by fat mass and obesity-associated protein …
[HTML][HTML] YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer
J Li, H Xie, Y Ying, H Chen, H Yan, L He, M Xu, X Xu… - Molecular cancer, 2020 - Springer
Abstract Background N6-methyladenosine (m 6 A) is the most abundant modification in
mRNA of humans. Emerging evidence has supported the fact that m 6 A is comprehensively …
mRNA of humans. Emerging evidence has supported the fact that m 6 A is comprehensively …
[HTML][HTML] Plants' response to abiotic stress: Mechanisms and strategies
Y Zhang, J Xu, R Li, Y Ge, Y Li, R Li - International Journal of Molecular …, 2023 - mdpi.com
Abiotic stress is the adverse effect of any abiotic factor on a plant in a given environment,
impacting plants' growth and development. These stress factors, such as drought, salinity …
impacting plants' growth and development. These stress factors, such as drought, salinity …
[HTML][HTML] RETRACTED ARTICLE: RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail
X Lin, G Chai, Y Wu, J Li, F Chen, J Liu, G Luo… - Nature …, 2019 - nature.com
Abstract N6-Methyladenosine (m6A) modification has been implicated in the progression of
several cancers. We reveal that during epithelial-mesenchymal transition (EMT), one …
several cancers. We reveal that during epithelial-mesenchymal transition (EMT), one …