Shikonin, a naphthalene ingredient: Therapeutic actions, pharmacokinetics, toxicology, clinical trials and pharmaceutical researches
Q Sun, T Gong, M Liu, S Ren, H Yang, S Zeng, H Zhao… - Phytomedicine, 2022 - Elsevier
Background Shikonin is one of the major phytochemical components of Lithospermum
erythrorhizon (Purple Cromwell), which is a type of medicinal herb broadly utilized in …
erythrorhizon (Purple Cromwell), which is a type of medicinal herb broadly utilized in …
The role of natural products in revealing NRF2 function
Covering: up to 2020 The transcription factor NRF2 is one of the body's major defense
mechanisms, driving transcription of> 300 antioxidant response element (ARE)-regulated …
mechanisms, driving transcription of> 300 antioxidant response element (ARE)-regulated …
[HTML][HTML] Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 …
LT Guo, SQ Wang, J Su, LX Xu, ZY Ji, RY Zhang… - Journal of …, 2019 - Springer
Background Baicalin, which is isolated from Radix Scutellariae, possesses strong biological
activities including an anti-inflammation property. Recent studies have shown that the anti …
activities including an anti-inflammation property. Recent studies have shown that the anti …
Targeting Nrf2/Keap1 signaling pathway by bioactive natural agents: Possible therapeutic strategy to combat liver disease
Background Nuclear factor erythroid 2-related factor (Nrf2), a stress-activated transcription
factor, has been documented to induce a defense mechanism against oxidative stress …
factor, has been documented to induce a defense mechanism against oxidative stress …
Current etiological comprehension and therapeutic targets of acetaminophen-induced hepatotoxicity
A Chowdhury, J Nabila, IA Temitope, S Wang - Pharmacological research, 2020 - Elsevier
Acetaminophen (APAP) is the most popular mild analgesic and antipyretic drug used
worldwide. APAP overdose leads to drug-induced hepatotoxicity and can cause hepatic …
worldwide. APAP overdose leads to drug-induced hepatotoxicity and can cause hepatic …
[HTML][HTML] Bone marrow mesenchymal stem cell-derived small extracellular vesicles promote liver regeneration via miR-20a-5p/PTEN
J Zhang, J Gao, X Li, D Lin, Z Li, J Wang… - Frontiers in …, 2023 - frontiersin.org
Balancing hepatocyte death and proliferation is key to non-transplantation treatments for
acute liver failure (ALF), which has a high short-term mortality rate. Small extracellular …
acute liver failure (ALF), which has a high short-term mortality rate. Small extracellular …
[HTML][HTML] Smilax china L. Polysaccharide Alleviates Oxidative Stress and Protects From Acetaminophen-Induced Hepatotoxicity via Activating the Nrf2-ARE Pathway
K Wang, L Yang, J Zhou, X Pan, Z He, J Liu… - Frontiers in …, 2022 - frontiersin.org
The alleviation of oxidative stress is considered an effective treatment for acetaminophen
(APAP)-induced acute liver injury (AILI). However, it remains unknow whether the potential …
(APAP)-induced acute liver injury (AILI). However, it remains unknow whether the potential …
Selenium Ameliorates Acetaminophen-Induced Oxidative Stress via MAPK and Nrf2 Pathways in Mice
MC Indumathi, K Swetha, KV Abhilasha… - … Trace Element Research, 2024 - Springer
Overdose of acetaminophen (paracetamol), a widely used non-prescriptive analgesic and
antipyretic medication, is one of the main causes of drug-induced acute liver failure around …
antipyretic medication, is one of the main causes of drug-induced acute liver failure around …
[HTML][HTML] Acetaminophen-induced apoptosis: Facts versus fiction
H Jaeschke, A Ramachandran - Journal of Clinical and …, 2020 - ncbi.nlm.nih.gov
An overdose of the widely used analgesic acetaminophen (APAP) is the most common
cause of acute liver failure in the western world and hence is a clinically significant problem …
cause of acute liver failure in the western world and hence is a clinically significant problem …
[HTML][HTML] Tentatively Identified (UPLC/T-TOF–MS/MS) Compounds in the Extract of Saussurea costus Roots Exhibit In Vivo Hepatoprotection via Modulation of HNF-1α …
HA El Gizawy, AE El-Haddad, AM Saadeldeen… - Molecules, 2022 - mdpi.com
Saussurea costus is a plant traditionally used for the treatment of several ailments. Our study
accomplished the UPLC/T-TOF–MS/MS analysis of a methanol extract of Saussurea costus …
accomplished the UPLC/T-TOF–MS/MS analysis of a methanol extract of Saussurea costus …