Animal models of Alzheimer disease: historical pitfalls and a path forward

SE Cavanaugh, JJ Pippin, ND Barnard - ALTEX-Alternatives to animal …, 2014 - altex.org
Alzheimer disease (AD) is a medically and financially overwhelming condition, and
incidence rates are expected to triple by 2050. Despite decades of research in animal …

Moderate-to-high intensity physical exercise in patients with Alzheimer's disease: a randomized controlled trial

K Hoffmann, NA Sobol, KS Frederiksen… - Journal of …, 2016 - content.iospress.com
Background: Studies of physical exercise in patients with Alzheimer's disease (AD) are few
and results have been inconsistent. Objective: To assess the effects of a moderate-to-high …

The impact of obesity and exercise on cognitive aging

JSY Chan, JH Yan, VG Payne - Frontiers in aging neuroscience, 2013 - frontiersin.org
Obesity is a major concern in the aging population and degrades health, motor functions
and cognition in older adults. The effects of obesity are pervasive and challenging to health …

Exploring the bidirectional associations between loneliness and cognitive functioning over 10 years: the English longitudinal study of ageing

J Yin, C Lassale, A Steptoe… - International journal of …, 2019 - academic.oup.com
Background As the population ages, cognitive decline and dementia have become major
health concerns in the UK. Loneliness has been linked to cognitive decline, but the reverse …

Moderate-intensity physical activity, hippocampal volume, and memory in older adults with mild cognitive impairment

H Makizako, T Liu-Ambrose, H Shimada… - … Series A: Biomedical …, 2015 - academic.oup.com
Background. Greater physical activity (PA) is associated with better memory performance
and greater hippocampal volume in older adults. However, most studies to date assessed …

Life experience and demographic influences on cognitive function in older adults.

PWH Brewster, RJ Melrose, MJ Marquine… - …, 2014 - psycnet.apa.org
Objective: We examined the influence of a broad spectrum of life experiences on
longitudinal cognitive trajectories in a demographically diverse sample of older adults …

Physical activity is positively associated with episodic memory in aging

SM Hayes, ML Alosco, JP Hayes, M Cadden… - Journal of the …, 2015 - cambridge.org
Aging is associated with performance reductions in executive function and episodic memory,
although there is substantial individual variability in cognition among older adults. One factor …

The role of physical and cognitive function in performance of activities of daily living in patients with mild-to-moderate Alzheimer's disease–a cross-sectional study

FK Clemmensen, K Hoffmann, V Siersma, N Sobol… - BMC geriatrics, 2020 - Springer
Background Several factors may play a role in the ability of patients with Alzheimer's disease
to perform activities of daily living (ADL). The aim of this study was to examine the impact of …

[HTML][HTML] Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise

CS Jensen, AH Simonsen, V Siersma, N Beyer… - Alzheimer's & Dementia …, 2019 - Elsevier
Introduction Our group has completed an exercise study of 200 patients with mild
Alzheimer's disease. We found improvements in cognitive, neuropsychiatric, and physical …

Light physical activity is positively associated with cognitive performance in older community dwelling adults

LG Johnson, ML Butson, RC Polman, IS Raj… - Journal of science and …, 2016 - Elsevier
Objectives To evaluate the associations between an objective measure of different
intensities of physical activity, upper-and lower-limb muscle strength and psychomotor …