[HTML][HTML] Roles of mitochondrial unfolded protein response in mammalian stem cells
LF Gu, JQ Chen, QY Lin, YZ Yang - World Journal of Stem Cells, 2021 - ncbi.nlm.nih.gov
The mitochondrial unfolded protein response (UPR mt) is an evolutionarily conserved
adaptive mechanism for improving cell survival under mitochondrial stress. Under …
adaptive mechanism for improving cell survival under mitochondrial stress. Under …
[HTML][HTML] Post-passage rock inhibition induces cytoskeletal aberrations and apoptosis in human embryonic stem cells
L Gao, SC Nath, X Jiao, R Zhou, S Nishikawa… - Stem cell …, 2019 - Elsevier
Human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) are
prone to anoikis after single cell dissociation. The small molecule, Y-27632 is known to …
prone to anoikis after single cell dissociation. The small molecule, Y-27632 is known to …
scAAV2-mediated C3 transferase gene therapy in a rat model with retinal ischemia/reperfusion injuries
J Tan, X Zhang, D Li, G Liu, Y Wang, D Zhang… - … Therapy Methods & …, 2020 - cell.com
Glaucoma is characterized by retinal ganglion cell (RGC) death and axonal loss. Therefore,
neuroprotection is important in treating glaucoma. In this study, we explored whether …
neuroprotection is important in treating glaucoma. In this study, we explored whether …
An in-silico sequence-structure-function analysis of the N-terminal lobe in CT group bacterial ADP-ribosyltransferase toxins
MR Lugo, AR Merrill - Toxins, 2019 - mdpi.com
The C3-like toxins are single-domain proteins that represent a minimal mono-ADP-ribosyl
transferase (mART) enzyme with a simple model scaffold for the entire cholera toxin (CT) …
transferase (mART) enzyme with a simple model scaffold for the entire cholera toxin (CT) …
Potentiation of Brain-Derived Neurotrophic Factor-Induced Protection of Spiral Ganglion Neurons by C3 Exoenzyme/Rho Inhibitor
J Harre, L Heinkele, M Steffens, A Warnecke… - Frontiers in Cellular …, 2021 - frontiersin.org
Preservation of the excitability of spiral ganglion neurons (SGN) may contribute to an
improved speech perception after cochlear implantation. Thus, the application of exogenous …
improved speech perception after cochlear implantation. Thus, the application of exogenous …
Cell-instructive alginate hydrogels targeting RhoA
Cellular processes involve dynamic rearrangement of the cytoskeleton. The GTPase RhoA
plays a fundamental role in controlling cytoskeletal architecture. The phenotypic stability of …
plays a fundamental role in controlling cytoskeletal architecture. The phenotypic stability of …
In vivo assessment of cell death and nigrostriatal pathway integrity following continuous expression of C3 transferase
RV Gupta, AJ Santiago-Lopez, K Berglund, RE Gross… - Neuroscience, 2020 - Elsevier
The bacterial exoenzyme C3 transferase (C3) irreversibly inhibits RhoA GTPase leading to
stimulation of axonal outgrowth in injured neurons. C3 has been used successfully in …
stimulation of axonal outgrowth in injured neurons. C3 has been used successfully in …
[PDF][PDF] MOLECULAR MECHANISMS OF TUMOR CELL RESISTANCE TO THE FGFR KINASE INHIBITOR
G Branch - 2023 - repolis.bg.polsl.pl
Pragnę serdecznie podziękować mojej Promotorce Pani prof. dr hab. Katarzynie Lisowskiej
za umożliwienie mi rozpoczęcia kariery naukowej i za pomoc w utrzymaniu się na tej …
za umożliwienie mi rozpoczęcia kariery naukowej i za pomoc w utrzymaniu się na tej …
[HTML][HTML] Anti-proliferative effect of C3 exoenzyme in fibroblasts is mediated by c-Jun phosphorylation
L von Elsner, S Hagemann, I Just… - Journal of molecular …, 2017 - ncbi.nlm.nih.gov
The ADP-ribosyltransferase C3 exoenzyme from C. botulinum selectively inactivates Rho
and is therefore often used as an inhibitor for investigations on Rho signaling. Previous …
and is therefore often used as an inhibitor for investigations on Rho signaling. Previous …
Proteínas multifuncionales, enfermedades humanas y dianas farmacológicas: una actualización
JF Rojas Cabeza - 2020 - openaccess.uoc.edu
La multifuncionalidad de proteínas se refiere a su habilidad para llevar a cabo un cabo dos
o más funciones biológicas. El objetivo de este trabajo fue examinar con herramientas …
o más funciones biológicas. El objetivo de este trabajo fue examinar con herramientas …