The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

The molecular signatures of epigenetic regulation and chromatin architectures are
fundamental to genetically determined biological processes. Covalent and post-translational …

Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

Progressive myoclonus epilepsies (PMEs) comprise a group of clinically and genetically
heterogeneous rare diseases. Over 70% of PME cases can now be molecularly solved …

The human ether-à-go-go related gene (hERG) K+ channel is of great interest for both basic
researchers and clinicians because its blockade by drugs can lead to QT prolongation …

Two decades of research have proven the relevance of ion channel expression for tumor
progression in virtually every indication, and it has become clear that inhibition of specific …

In congenital and acquired long QT type 2, women are more vulnerable than men to
Torsade de Pointes. In prepubertal rabbits (and children), the arrhythmia phenotype is …

We summarize recent advances in the clinical genetics of hypercholesterolemia,
hypertrophic cardiomyopathy (HCM), and lethal arrhythmia, all of which are monogenic …

Voltage-gated potassium (Kv) channels generate the outward K+ ion currents that constitute
the primary force in ventricular repolarization. Voltage-gated potassium channels comprise …

Blockade of the human ether-a-go-go related gene 1 (hERG1) channel has been associated
with an increased duration of ventricular repolarization, causing prolongation of the time …