APOE Peripheral and Brain Impact: APOE4 Carriers Accelerate Their Alzheimer Continuum and Have a High Risk of Suicide in PM2.5 Polluted Cities
L Calderón-Garcidueñas, J Hernández-Luna… - Biomolecules, 2023 - mdpi.com
This Review emphasizes the impact of APOE4—the most significant genetic risk factor for
Alzheimer's disease (AD)—on peripheral and neural effects starting in childhood. We …
Alzheimer's disease (AD)—on peripheral and neural effects starting in childhood. We …
Damage to the Locus Coeruleus Alters the Expression of Key Proteins in Limbic Neurodegeneration
F Biagioni, M Ferrucci, G Lazzeri, M Scioli… - International Journal of …, 2024 - mdpi.com
The present investigation was designed based on the evidence that, in neurodegenerative
disorders, such as Alzheimer's dementia (AD) and Parkinson's disease (PD), damage to the …
disorders, such as Alzheimer's dementia (AD) and Parkinson's disease (PD), damage to the …
Selective Vulnerability to Neurodegenerative Disease: Insights from Cell Type-Specific Translatome Studies
Simple Summary Neurodegenerative diseases, such as Alzheimer's, Parkinson's, and
Huntington's diseases, cause immense suffering to patients and their families. Despite an …
Huntington's diseases, cause immense suffering to patients and their families. Despite an …
Repeated Methamphetamine Administration Results in Axon Loss Prior to Somatic Loss of Substantia Nigra Pars Compacta and Locus Coeruleus Neurons in Male …
A Pilski, SM Graves - International journal of molecular sciences, 2023 - mdpi.com
Methamphetamine (meth) is a neurotoxic psychostimulant that increases monoamine
oxidase (MAO)-dependent mitochondrial oxidant stress in axonal but not somatic …
oxidase (MAO)-dependent mitochondrial oxidant stress in axonal but not somatic …
[HTML][HTML] Lower in vivo locus coeruleus integrity is associated with lower cortical thickness in older individuals with elevated Alzheimer's pathology: a cohort study
N Engels-Domínguez, EA Koops, S Hsieh… - … Research & Therapy, 2024 - ncbi.nlm.nih.gov
Background Autopsy work indicates that the widely-projecting noradrenergic pontine locus
coeruleus (LC) is among the earliest regions to accumulate hyperphosphorylated tau, a …
coeruleus (LC) is among the earliest regions to accumulate hyperphosphorylated tau, a …
Combined in vivo MRI assessment of locus coeruleus and nucleus basalis of Meynert integrity in amnestic Alzheimer's disease, suspected-LATE and frontotemporal …
J Lagarde, P Olivieri, M Tonietto, C Noiray… - Alzheimer's Research & …, 2024 - Springer
Background The locus coeruleus (LC) and the nucleus basalis of Meynert (NBM) are altered
in early stages of Alzheimer's disease (AD). Little is known about LC and NBM alteration in …
in early stages of Alzheimer's disease (AD). Little is known about LC and NBM alteration in …
Structure characterisation of polysaccharides purified from Boletus aereus Bull. and its improvement on AD-like behaviours via reliving neuroinflammation in APP/PS1 …
Y Zhu, L Li, X Jin, Z Li, C Wang, L Teng, Y Li… - International Journal of …, 2024 - Elsevier
The water-soluble neutral polysaccharide BEP2, with a molecular weight of 26.65 kDa, was
isolated from the aqueous extract obtained from the fruiting bodies of Boletus aereus Bull …
isolated from the aqueous extract obtained from the fruiting bodies of Boletus aereus Bull …
Neurodegenerative Disease: From Molecular Basis to Therapy
C Ricci - International Journal of Molecular Sciences, 2024 - mdpi.com
Neurodegenerative diseases are a heterogeneous group of age-related disorders
characterised by the progressive degeneration or death of neurons in the central or …
characterised by the progressive degeneration or death of neurons in the central or …
Analysis of the cognitive and functional behavior of female rats in the periestropause after hormone therapy with estrogen
TD Esperança, BP Stringhetta-Villar… - Behavioural Brain …, 2024 - Elsevier
Perimenopause is a critical period, with severe cycle irregularity and lower estrogen
secretion altering redox state biomarkers, leading to behavioral changes. The estrogen …
secretion altering redox state biomarkers, leading to behavioral changes. The estrogen …
Transcutaneous Cervical Vagus Nerve Magnetic Stimulation in Patients With Traumatic Brain Injury: A Feasibility Study
H Zhang, Y Zhao, Y Qu, J Du, Y Peng - Neuromodulation: Technology at …, 2023 - Elsevier
Objectives Transcutaneous vagus nerve stimulation has shown promising results in
improving cognitive and motor function after stroke. However, to our knowledge, there have …
improving cognitive and motor function after stroke. However, to our knowledge, there have …