Adverse effects of nutraceuticals and dietary supplements
MJJ Ronis, KB Pedersen, J Watt - Annual review of …, 2018 - annualreviews.org
Over 70% of Americans take some form of dietary supplement every day, and the
supplement industry is currently big business, with a gross of over $28 billion. However …
supplement industry is currently big business, with a gross of over $28 billion. However …
Bile acid receptors as targets for drug development
The intracellular nuclear receptor farnesoid X receptor and the transmembrane G protein-
coupled receptor TGR5 respond to bile acids by activating transcriptional networks and/or …
coupled receptor TGR5 respond to bile acids by activating transcriptional networks and/or …
Inhibitory effect of phenolic compounds and plant extracts on the formation of advance glycation end products: A comprehensive review
M Khan, H Liu, J Wang, B Sun - Food Research International, 2020 - Elsevier
Advance glycation end products (AGEs) are a diverse group of compounds formed through
the non-enzymatic maillard reaction of reducing sugars with the free amino groups in …
the non-enzymatic maillard reaction of reducing sugars with the free amino groups in …
Dietary phytochemicals as modulators of human pregnane X receptor
As a promiscuous xenobiotic sensor, pregnane X receptor (PXR) plays a crucial role in drug
metabolism. Since dietary phytochemicals exhibit the potential to modulate human PXR, this …
metabolism. Since dietary phytochemicals exhibit the potential to modulate human PXR, this …
Unpredictable adverse effects of herbal products
N Başaran, D Paslı, AA Başaran - Food and Chemical Toxicology, 2022 - Elsevier
Herbal products are being increasingly used all over the world for preventive and
therapeutic purposes because of the belief of their safety. They have become an important …
therapeutic purposes because of the belief of their safety. They have become an important …
[HTML][HTML] Effects of bile acids on neurological function and disease
M McMillin, S DeMorrow - The FASEB Journal, 2016 - ncbi.nlm.nih.gov
Bile acids are synthesized from cholesterol and are known to be involved with the
emulsification and digestion of dietary lipids and fat-soluble vitamins. Outside of this role …
emulsification and digestion of dietary lipids and fat-soluble vitamins. Outside of this role …
[HTML][HTML] Nuclear receptor PXR, transcriptional circuits and metabolic relevance
CA Ihunnah, M Jiang, W Xie - … et Biophysica Acta (BBA)-Molecular Basis of …, 2011 - Elsevier
The pregnane X receptor (PXR, NR1I2) is a ligand activated transcription factor that belongs
to the nuclear hormone receptor (NR) superfamily. PXR is highly expressed in the liver and …
to the nuclear hormone receptor (NR) superfamily. PXR is highly expressed in the liver and …
Targeting xenobiotic receptors PXR and CAR for metabolic diseases
J Gao, W Xie - Trends in pharmacological sciences, 2012 - cell.com
The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are two
closely related and liver-enriched nuclear hormone receptors originally defined as …
closely related and liver-enriched nuclear hormone receptors originally defined as …
[HTML][HTML] The mechanisms of inhibition of advanced glycation end products formation through polyphenols in hyperglycemic condition
Glycation, the non-enzymatic binding of glucose to free amino groups of an amino acid,
yields irreversible heterogeneous compounds known as advanced glycation end products …
yields irreversible heterogeneous compounds known as advanced glycation end products …
[HTML][HTML] Nuclear receptors in drug metabolism, drug response and drug interactions
C Prakash, B Zuniga, CS Song, S Jiang… - Nuclear receptor …, 2015 - ncbi.nlm.nih.gov
Orally delivered small-molecule therapeutics are metabolized in the liver and intestine by
phase I and phase II drug-metabolizing enzymes (DMEs), and transport proteins coordinate …
phase I and phase II drug-metabolizing enzymes (DMEs), and transport proteins coordinate …