Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …

Both aging and cancer are characterized by a series of partially overlapping" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …

Advanced glycation end-products (AGEs) constitute a non-homogenous, chemically diverse
group of compounds formed either exogeneously or endogeneously on the course of …

Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …

Macrophages are versatile and heterogeneous innate immune cells undertaking central
functions in balancing immune responses and tissue repair to maintain homeostasis. This …

The mutational landscape of colorectal cancer (CRC) does not enable predictions to be
made about the survival of patients or their response to therapy. Instead, studying the …

Cancer development is closely associated with immunosuppressive tumor
microenvironment (TME) that attenuates antitumor immune responses and promotes tumor …

The natural mammalian polyamines putrescine, spermidine and spermine are essential for
both normal and neoplastic cell function and replication. Dysregulation of metabolism of …

Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the
specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged …