CNS inflammation and macrophage/microglial biology associated with HIV-1 infection
A Yadav, RG Collman - Journal of neuroimmune pharmacology, 2009 - Springer
Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS)
can result in neurological dysfunction with devastating consequences in a significant …
can result in neurological dysfunction with devastating consequences in a significant …
Role of Tat protein in HIV neuropathogenesis
W Li, G Li, J Steiner, A Nath - Neurotoxicity research, 2009 - Springer
The Tat protein of the human immunodeficiency virus (HIV) has been implicated in the
pathophysiology of the neurocognitive deficits associated with HIV infection. This is the …
pathophysiology of the neurocognitive deficits associated with HIV infection. This is the …
HIV-1 Tat enhances purinergic P2Y4 receptor signaling to mediate inflammatory cytokine production and neuronal damage via PI3K/Akt and ERK MAPK pathways
F Zhou, X Liu, L Gao, X Zhou, Q Cao, L Niu… - Journal of …, 2019 - Springer
Background HIV-associated neurocognitive disorders (HANDs) afflict more than half of HIV-
1-positive individuals. The transactivator of transcription (Tat) produced by HIV virus elicits …
1-positive individuals. The transactivator of transcription (Tat) produced by HIV virus elicits …
Synergistic up-regulation of CXCL10 by virus and IFN γ in human airway epithelial cells
KL Oslund, X Zhou, B Lee, L Zhu, T Duong, R Shih… - PloS one, 2014 - journals.plos.org
Airway epithelial cells are the first line of defense against viral infections and are
instrumental in coordinating the inflammatory response. In this study, we demonstrate the …
instrumental in coordinating the inflammatory response. In this study, we demonstrate the …
HIV-1 Tat activates indoleamine 2, 3 dioxygenase in murine organotypic hippocampal slice cultures in a p38 mitogen-activated protein kinase-dependent manner
Background We have established that activation of the tryptophan degrading enzyme
indoleamine 2, 3 dioxygenase (IDO) mediates the switch from cytokine-induced sickness …
indoleamine 2, 3 dioxygenase (IDO) mediates the switch from cytokine-induced sickness …
Role of HIV-1 Tat in AIDS pathogenesis: its effects on cytokine dysregulation and contributions to the pathogenesis of opportunistic infection
HIV is the primary etiological agent of AIDS. Effective treatment and prevention of HIV
remain a top priority for governments and international health authorities worldwide …
remain a top priority for governments and international health authorities worldwide …
Smoking decreases the response of human lung macrophages to double-stranded RNA by reducing TLR3 expression
JC Todt, CM Freeman, JP Brown, J Sonstein… - Respiratory …, 2013 - Springer
Background Cigarette smoking is associated with increased frequency and duration of viral
respiratory infections, but the underlying mechanisms are incompletely defined. We …
respiratory infections, but the underlying mechanisms are incompletely defined. We …
Cooperative induction of CXCL10 involves NADPH oxidase: Implications for HIV dementia
R Williams, H Yao, F Peng, Y Yang, C Bethel‐Brown… - Glia, 2010 - Wiley Online Library
With the increasing prevalence of HIV‐associated neurocognititve disorders (HAND),
understanding the mechanisms by which HIV‐1 induces neuro‐inflammation and …
understanding the mechanisms by which HIV‐1 induces neuro‐inflammation and …
Low levels of peripheral blood activated and senescent T cells characterize people with HIV-1-associated neurocognitive disorders
L Kundura, R Cezar, M Pastore, C Reynes… - Frontiers in …, 2023 - frontiersin.org
Background HIV infection induces a 75% increase in the risk of developing neurocognitive
impairment (NCI), which has been linked to immune activation. We therefore looked for …
impairment (NCI), which has been linked to immune activation. We therefore looked for …
HIV neuropathogenesis: a tight rope walk of innate immunity
H Yao, C Bethel-Brown, CZ Li, SJ Buch - Journal of Neuroimmune …, 2010 - Springer
During the course of HIV-1 disease, virus neuroinvasion occurs as an early event, within
weeks following infection. Intriguingly, subsequent central nervous system (CNS) …
weeks following infection. Intriguingly, subsequent central nervous system (CNS) …