Sleep deprivation (SD) is a powerful antidepressant treatment that shows antidepressant
responses within hours in 40–60% of depressed patients. In more than 80% of responders …

Current antidepressants are ineffective in many depressed patients. Thus there is an urgent
need to develop treatment strategies which have significantly faster response, can be …

Background: Several studies of healthy volunteers have revealed that subjective mood may
vary with the duration of prior wakefulness and with the time of day. However, in these …

Background Fluvoxamine, one of the oldest selective serotonin reuptake inhibitors (SSRIs),
is prescribed to patients with major depression in many countries. Several studies have …

Background: While the majority of depressed patients benefit from total sleep deprivation
(TSD), light therapy is regarded as a first-line treatment only for seasonal affective disorder …

Catechol-O-methyltransferase (COMT) inactivates norepinephrine and dopamine via methyl
conjugation, and a G–A transition in the COMT gene (rs4680) influences the enzyme activity …

The possible predictive value of regional cerebral perfusion patterns with respect to the
response to partial sleep deprivation (PSD) was evaluated in 15 major depressive patients …

Objective: Therapeutic sleep deprivation (SD) is a nonpharmacological treatment that is
used most often for depression. The aim of this study was to examine the pattern of use of …

Three patients with treatment‐resistant rapidly cycling bipolar disorder were studied with
multiple sleep deprivations (SD) during several depressive episodes to assess the effect of …

Im Zusammenhang mit der nicht-pharmakologischen Behandlung depressiver Syndrome
wurden verschiedene Veränderungen des Schlaf-Wach-Rhythmus beschrieben (zur …