Traumatic spinal cord injury (SCI) is a devastating condition of motor, sensory, and
autonomic dysfunction. The significant cost associated with the management and lifetime …

Amyotrophic lateral sclerosis (ALS) is a chronic, progressive neurodegenerative disease
characterized by the loss of motor neurons. Dysregulated peripheral immunity has been …

SYNOPSIS Signal Transducers and Activators of Transcription (STATs) comprise a family of
transcription factors that mediate a wide variety of biological functions in the central and …

Granulocyte colony stimulating factor (G-CSF) is a multi-modal hematopoietic growth factor,
which also has profound effects on the diseased CNS. G-CSF has been shown to enhance …

Hematopoietic stem cells (HSC) reside in perivascular regions of the bone marrow (BM)
embedded within a complex regulatory unit called the niche. Cellular components of HSC …

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic cytokine
responsible for the proliferation, differentiation, and maturation of cells of the myeloid …

We investigated the molecular mechanisms of the anti-apoptotic properties of granulocyte-
colony stimulating factor (G-CSF) on neurons and whether G-CSF affects glial cell survival …

Background and Purpose—Granulocyte colony–stimulating factor (G-CSF; AX200;
Filgrastim) is a stroke drug candidate with excellent preclinical evidence for efficacy. A …

Human neurological disorders such as Alzheimer's disease (AD), Parkinson's disease,
stroke or spinal cord injury are caused by the loss of neurons and glial cells in the brain or …

Neonatal hypoxic–ischemic (HI) brain injury likely represents the major cause of long-term
neurodevelopmental disabilities in surviving babies. Despite significant investigations, there …