Recent clinical and preclinical evidence suggests that psychedelics and entactogens may
produce both rapid and sustained therapeutic effects across several indications. Currently …

Ketamine, a dissociative anesthetic and psychedelic compound, has revolutionized the field
of psychopharmacology by showing robust, and rapid-acting antidepressant activity in …

Alterations in energy metabolism are associated with depression. However, the role of
glycolysis in the pathogenesis of depression and the underlying molecular mechanisms …

Chronic stress exposure induces maladaptive behavioral responses and increases
susceptibility to neuropsychiatric conditions. However, specific neuronal populations and …

Dysregulation of adult hippocampal neurogenesis is linked to major depressive disorder
(MDD), with more than 300 million people diagnosed and worsened by the COVID‐19 …

Depression is a complex and highly heterogeneous disorder which diagnosis is based on
an exceedingly variable set of clinical symptoms. Current treatments focus almost …

Depression and anxiety are major global health burdens. Although SSRIs targeting the
serotonergic system are prescribed over 200 million times annually, they have variable …

Background Subanesthetic ketamine has accumulated meta-analytic evidence for rapid
antidepressant effects in treatment-resistant depression (TRD), resulting in both excitement …

Repurposing ketamine in the therapy of depression could well represent a breakthrough in
understanding the etiology of depression. Ketamine was originally used as an anesthetic …

The drug ketamine has been extensively studied due to its use in anaesthesia, as a model of
psychosis and, most recently, its antidepressant properties. Understanding the physiology of …