Alpha‐amylase as molecular target for treatment of diabetes mellitus: A comprehensive review
The alpha (α)‐amylase is a calcium metalloenzyme that aids digestion by breaking down
polysaccharide molecules into smaller ones such as glucose and maltose. In addition, the …
polysaccharide molecules into smaller ones such as glucose and maltose. In addition, the …
Recent applications of the multicomponent synthesis for bioactive pyrazole derivatives
D Becerra, R Abonia, JC Castillo - Molecules, 2022 - mdpi.com
Pyrazole and its derivatives are considered a privileged N-heterocycle with immense
therapeutic potential. Over the last few decades, the pot, atom, and step economy (PASE) …
therapeutic potential. Over the last few decades, the pot, atom, and step economy (PASE) …
In vitro and in silico studies of fluorinated 2, 3‐disubstituted thiazolidinone‐pyrazoles as potential α‐amylase inhibitors and antioxidant agents
As part of our effort to identify potent α‐amylase inhibitors, in the present study, a novel
series of fluorinated thiazolidinone‐pyrazole hybrid molecules were prepared by the …
series of fluorinated thiazolidinone‐pyrazole hybrid molecules were prepared by the …
Parsing structural fragments of thiazolidin-4-one based α-amylase inhibitors: A combined approach employing in vitro colorimetric screening and GA-MLR based …
Abstract α-Amylase (EC. 3.2. 1.1) is a ubiquitous digestive endoamylase. The abrupt rise in
blood glucose levels due to the hydrolysis of carbohydrates by α-amylase at a faster rate is …
blood glucose levels due to the hydrolysis of carbohydrates by α-amylase at a faster rate is …
Exploring biological efficacy of novel benzothiazole linked 2, 5-disubstituted-1, 3, 4-oxadiazole hybrids as efficient α-amylase inhibitors: Synthesis, characterization …
In an effort to explore a class of novel antidiabetic agents, we have made an effort to
synergize the α-amylase inhibitory potential of 1, 3-benzothiazole and 1, 3, 4-oxadiazole …
synergize the α-amylase inhibitory potential of 1, 3-benzothiazole and 1, 3, 4-oxadiazole …
Quasi-SMILES as a basis for the development of QSPR models to predict the CO2 capture capacity of deep eutectic solvents using correlation intensity index and …
The interpretation of the CO 2 capture capacity of the deep eutectic solvents (DESs) as a
mathematical function of (i) hydrogen bond acceptor (HBA);(ii) hydrogen bond donor …
mathematical function of (i) hydrogen bond acceptor (HBA);(ii) hydrogen bond donor …
CORAL: development of a hybrid descriptor based QSTR model to predict the toxicity of dioxins and dioxin-like compounds with correlation intensity index and …
In the present study, ninety-five halogenated dioxins and related chemicals (dibenzo-p-
dioxins, dibenzofurans, biphenyls, and naphthalene) with endpoint pEC 50 were used to …
dioxins, dibenzofurans, biphenyls, and naphthalene) with endpoint pEC 50 were used to …
Quantitative structure activity relationship studies of novel hydrazone derivatives as α-amylase inhibitors with index of ideality of correlation
The present manuscript describes the synthesis, α-amylase inhibition, in silico studies and in-
depth quantitative structure–activity relationship (QSAR) of a library of aroyl hydrazones …
depth quantitative structure–activity relationship (QSAR) of a library of aroyl hydrazones …
The Monte Carlo approach to model and predict the melting point of imidazolium ionic liquids using hybrid optimal descriptors
Ionic liquids (ILs) have captured intensive attention owing to their unique properties such as
high thermal stability, negligible vapour pressure, high dissolution capacity and high ionic …
high thermal stability, negligible vapour pressure, high dissolution capacity and high ionic …
QSRR modelling for the investigation of gas chromatography retention indices of flavour and fragrance compounds on Carbowax 20 M glass capillary column with …
The goal of the present study was to use a quantitative structure-retention relationship
(QSRR) for the retention indices of 1179 flavour and fragrance organic compounds using the …
(QSRR) for the retention indices of 1179 flavour and fragrance organic compounds using the …