Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

Carbohydrate polymers with unique chemical composition, molecular weight and functional
chemical groups show multiple potentials in drug delivery. Most carbohydrate polymers such …

Introduction: Adverse immune activation contributes to many central nervous system (CNS)
disorders. All main CNS cell types express toll-like receptor 4 (TLR 4). This receptor is …

Bacteria have evolved multiple strategies to sense and rapidly adapt to challenging and
ever-changing environmental conditions. The ability to alter membrane lipid composition, a …

Phages, short for bacteriophages, are viruses that specifically infect bacteria and are the
most abundant biological entities on earth found in every explored environment, from the …

The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism.
The PPP is important to maintain carbon homoeostasis, to provide precursors for nucleotide …

Caloric restriction (CR) stimulates development of functional beige fat and extends healthy
lifespan. Here we show that compositional and functional changes in the gut microbiota …

Aminoglycoside antibiotics were among the first antibiotics discovered and used clinically.
Although they have never completely fallen out of favor, their importance has waned due to …

Background While human gut microbiomes vary significantly in taxonomic composition,
biological pathway abundance is surprisingly invariable across hosts. We hypothesized that …

The emergence of microbial resistance is becoming a global problem in clinical and
environmental areas. As such, the development of drugs with novel modes of action will be …